Malignant fibrous histiocytoma
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| Malignant fibrous histiocytoma Classification and external resources | |
| OMIM | 8830/3 |
|---|---|
| DiseasesDB | 31471 |
| eMedicine | radio/420 |
| MeSH | D051677 |
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Overview
Malignant fibrous histiocytoma (MFH) is a type of cancer that is the most common soft tissue sarcoma of late adult life, most commonly occurring between age 50-70. In rare cases MFH does occur in children, but it is usually in a less aggressive form. However, malignant tumors have occurred in children as young as 13. It occurs more often in caucasians than those of African or Asian descent. Its male:female predominance is 2:1.
Presentation
MFH occurs most commonly in the extremities and retroperitoneum, but has been reported in many other sites (lung, head/neck, etc.). Development of metastasis depends on the tumor's subtype. Metastasis occurs most frequently in the lung (90%), bone (8%) and liver (1%). In the extremities, it presents as a painless enlarging soft tissue mass. It can develop anywhere in the soft tissue, but also occurs at sites of previous radiation treatment, shrapnel implantation or next to prostheses.
It can be divided into two subtypes: "spindle cell" and "pleomorphic".[1]
Diagnosis
It can be detected by magnetic resonance imaging (MRI), but a biopsy is required for definitive diagnosis.
Treatment
Treatment consists of surgical removal (the extent of which ranges from tumor excision to limb amputation depending on the tumor) and in some cases chemotherapy.
Prognosis
Prognosis depends on the primary tumor size and grade (aggressiveness). 5-year survival ranges from 35-60%.
References
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
