Mammillary body
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| Brain: Mammillary body | ||
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| The hypophysis cerebri in position. Shown in sagittal section. (Label "corpus mamillare" at right.) | ||
| Coronal section of brain through intermediate mass of third ventricle. (Label "corpus mamillare" at bottom.) | ||
| Latin | corpus mamillare | |
| Gray's | subject #188 813 | |
| Part of | Midbrain | |
| System | Limbic | |
| Components | medial mammillary nucleus lateral mammillary nucleus | |
| Acronym(s) | mmb | |
| NeuroNames | hier-395 | |
| MeSH | Mamillary+Bodies | |
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The mammillary bodies are a pair of small round bodies, located on the undersurface of the brain, that form part of the limbic system. They are located at the ends of the anterior arches of the fornix, and are named mammillary for their resemblance to two breasts. They consist of two groups of nuclei, the medial mammillary nuclei and the lateral mammillary nuclei.
Neuroanatomists have often categorized the mammillary bodies as part of the hypothalamus.[1]
Connections
They are connected to other parts of the brain (as shown in the schematic, below left), and act as a relay for impulses coming from the amygdalae and hippocampi, via the mamillo-thalamic tract to the thalamus.
This circuit, from amygdalae to mamillary bodies, and then on to the thalamus, is part of the larger 'Papez circuit'.
Function
They are involved with the processing of recognition memory, along with the anterior and dorsomedial nuclei in the thalamus.
Pathology
The mammillary bodies are parts of the brain known to be significantly damaged by alcohol intoxication, especially by chronic alcohol abuse and associated deficiency of thiamine. Researchers, in 1998, also noted visible abnormalities in the mammillary bodies of individuals with autism.[1]
Damage to the mammillary bodies due to thiamine deficiency is implied in pathogenesis of Wernicke-Korsakoff syndrome. Symptoms include impaired memory, also called anterograde amnesia, suggesting that the mammillary bodies may be important for memory. Lesions of the medial dorsal and anterior nuclei of the thalami and lesions of the mammillary bodies are commonly involved in amnesic syndromes in humans.[1]
Additional images
Constudoverbrain.gif
Brain |
References
External links
- Vann S, Aggleton J (2004). "The mammillary bodies: two memory systems in one?". Nat. Rev. Neurosci. 5 (1): 35-44. PMID 14708002.
- TheFreeDictionary.com - 'Mammillary body'
- Roche Lexicon - illustrated navigator, at Elsevier 13048.000-3
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

