Marchiafava-Bignami disease

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Marchiafava-Bignami disease
Classification and external resources
DiseasesDB 31494
eMedicine neuro/204 

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Marchiafava-Bignami disease

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Overview

Marchiafava-Bignami disease is a progressive neurological disease characterized by corpus callosum demyelination and necrosis and subsequent atrophy. It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker. It is classically associated with chronic alcoholics who abuse cheap Italian red wine.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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