Matrix gla protein
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| Matrix Gla protein | |
|---|---|
| Symbol(s): | MGP |
| Genetic data | |
| Locus: | Chr. 12 p13.1-12.3 |
| Gene code: | MGP |
| Gene type: | protein coding |
| Protein Structure/Function | |
| Protein length: | 84 (Amino Acids) |
| Other | |
| Covalent modifications: | carboxylation |
| Medical/Biotechnological data | |
| Diseases: | Keutel syndrome |
| Database Links | |
| Entrez: | 4256 |
| OMIM: | 154870 |
| RefSeq: | NM_000900 |
| UniProt: | P08493 |
Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.
Genetics
The MGP was linked to the short arm of chromosome 12 in 1990.[1]
Physiology
MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.
Role in disease
Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition characterised by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia.[1]
References
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
