Mechlorethamine

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Image:Mechlorethamine.png
Mechlorethamine
Systematic (IUPAC) name
2-chloro-N-(2-chloroethyl)-N-methyl-ethanamine
Identifiers
CAS number	51-75-2
ATC code	L01AA05
PubChem	4033
DrugBank	APRD00249
Chemical data
Formula	C5H11Cl2N
Mol. mass	156.055 g mol−1
Pharmacokinetic data
Bioavailability	?
Metabolism	Rapid hydrolysis and demethylation, possibly in plasma
Half life	< 1 minute
Excretion	Urine (50% as metabolites, <0.01% as unchanged drug)
Therapeutic considerations
Pregnancy cat.	D (US)
Legal status	℞ Prescription only
Routes	IV, intracavitary, intrapericardially, topical

WikiDoc Resources for Mechlorethamine
Articles
Most recent articles on Mechlorethamine Most cited articles on Mechlorethamine Review articles on Mechlorethamine Articles on Mechlorethamine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Mechlorethamine Images of Mechlorethamine Photos of Mechlorethamine Podcasts & MP3s on Mechlorethamine Videos on Mechlorethamine
Evidence Based Medicine
Cochrane Collaboration on Mechlorethamine Bandolier on Mechlorethamine TRIP on Mechlorethamine
Clinical Trials
Ongoing Trials on Mechlorethamine at Clinical Trials.gov Trial results on Mechlorethamine Clinical Trials on Mechlorethamine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Mechlorethamine NICE Guidance on Mechlorethamine NHS PRODIGY Guidance FDA on Mechlorethamine CDC on Mechlorethamine
Books
Books on Mechlorethamine
News
Mechlorethamine in the news Be alerted to news on Mechlorethamine News trends on Mechlorethamine
Commentary
Blogs on Mechlorethamine
Definitions
Definitions of Mechlorethamine
Patient Resources / Community
Patient resources on Mechlorethamine Discussion groups on Mechlorethamine Patient Handouts on Mechlorethamine Directions to Hospitals Treating Mechlorethamine Risk calculators and risk factors for Mechlorethamine
Healthcare Provider Resources
Symptoms of Mechlorethamine Causes & Risk Factors for Mechlorethamine Diagnostic studies for Mechlorethamine Treatment of Mechlorethamine
Continuing Medical Education (CME)
CME Programs on Mechlorethamine
International
Mechlorethamine en Espanol Mechlorethamine en Francais
Businness
Mechlorethamine in the Marketplace Patents on Mechlorethamine
Experimental / Informatics
List of terms related to Mechlorethamine

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Overview

Mechlorethamine also known as chlormethine, mustine, nitrogen mustard and HN2 and sold under the brand name Mustargen, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from chemical warfare research, in particular a 1943 accident in Bari, Italy which exposed civilians and soldiers-- it was noted that white cell counts of exposed patients decreased, suggesting a possible therapy for the cancer Hodgkin's lymphoma. It belongs to the group of nitrogen mustard alkylating agents.

It has been derivatized into the estrogen analogue estramustine, used to treat prostate cancer.

It can also be used in chemical warfare where it has the code-name HN2. This chemical is a form of nitrogen mustard gas and therefore a powerful vesicant.

External links

• British Columbia Cancer Agency profile

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Mechlorethamine
Articles on Mechlorethamine	Most recent articles on Mechlorethamine • Most cited articles on Mechlorethamine • Review articles on Mechlorethamine • Articles on Mechlorethamine in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Mechlorethamine	Powerpoint slides on Mechlorethamine • Images of Mechlorethamine • Photos of Mechlorethamine • Podcasts & MP3s on Mechlorethamine • Videos on Mechlorethamine
Evidence Based Medicine Regarding Mechlorethamine	Cochrane Collaboration on Mechlorethamine • Bandolier on Mechlorethamine • TRIP on Mechlorethamine
Cost Effectiveness of Mechlorethamine	Cost Effectiveness of Mechlorethamine
Clinical Trials Involving Mechlorethamine	Ongoing Trials on Mechlorethamine at Clinical Trials.gov • Trial results on Mechlorethamine • Clinical Trials on Mechlorethamine at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Mechlorethamine	US National Guidelines Clearinghouse on Mechlorethamine • NICE Guidance on Mechlorethamine • NHS PRODIGY Guidance • FDA on Mechlorethamine • CDC on Mechlorethamine
Textbook Information on Mechlorethamine	Books and Textbook Information on Mechlorethamine
Pharmacology Resources on Mechlorethamine	Dosing of Mechlorethamine • Drug interactions with Mechlorethamine • Side effects of Mechlorethamine • Allergic reactions to Mechlorethamine • Overdose information on Mechlorethamine • Carcinogenicity information on Mechlorethamine • Mechlorethamine in pregnancy • Pharmacokinetics of Mechlorethamine •
Genetics, Pharmacogenomics, and Proteinomics of Mechlorethamine	Genetics of Mechlorethamine • Pharmacogenomics of Mechlorethamine • Proteomics of Mechlorethamine
Newstories on Mechlorethamine	Mechlorethamine in the news • Be alerted to news on Mechlorethamine • News trends on Mechlorethamine
Commentary on Mechlorethamine	Blogs on Mechlorethamine
Patient Resources on Mechlorethamine	Patient resources on Mechlorethamine • Discussion groups on Mechlorethamine • Patient Handouts on Mechlorethamine • Directions to Hospitals Treating Mechlorethamine • Risk calculators and risk factors for Mechlorethamine
Healthcare Provider Resources on Mechlorethamine	Symptoms of Mechlorethamine • Causes & Risk Factors for Mechlorethamine • Diagnostic studies for Mechlorethamine • Treatment of Mechlorethamine
Continuing Medical Education (CME) Programs on Mechlorethamine	CME Programs on Mechlorethamine
International Resources on Mechlorethamine	Mechlorethamine en Espanol • Mechlorethamine en Francais
Business Resources on Mechlorethamine	Mechlorethamine in the Marketplace • Patents on Mechlorethamine
Informatics Resources on Mechlorethamine	List of terms related to Mechlorethamine

de:Mechlorethamin

it:Mecloretamina

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .