Meclizine
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Image:Meclizine.svg | |
| Meclizine
| |
| Systematic (IUPAC) name | |
| 1-[(4-chlorophenyl)- phenyl-methyl]-4- [(3-methylphenyl)methyl]piperazine | |
| Identifiers | |
| CAS number | |
| ATC code | A04 R06AE05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C25H27ClN2 |
| Mol. mass | 390.948 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 6 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B |
| Legal status | |
| Routes | Oral |
Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinate (Dramamine), meclizine is considered to be equally effective, but with reduced side effects.
Uses
Motion sickness
Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.
Vertigo
Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.
Risks of use
Drowsiness
Drowsiness may result as a side effect of taking meclizine. While the effects are less than dimenhydrinate, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of meclizine may result in additional drowsiness.
Pregnancy
Meclizine is classified as Pregnancy Category B by the FDA.
Category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Studies have shown that cleft palates of fetuses were formed when pregnant rats were exposed to 25-50 times a normal dosage. Thus, pregnant women are advised not to take meclizine unless it is absolutely necessary.
Anticholinergics
Due to its possible anticholinergic action, meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.
Commercial names
Meclizine hydrochloride is sold under the commercial names
- Dramamine II®
- Dramamine Less Drowsy®
- Antivert®
- Bonine®
- Bonamine®
- Bonikraft®
- Emetostop®
- Medivert®
- Sea-Legs®
- Agyrax®
- Postafen® (Sweden)
External links
- [1] – University of Berlin's Institute of Biochemistry
- [2] – Numark Pharmacies Information Page on Meclizine
- [3] Rxlist Medical Dictionary
hu:Meklizin nn:Meklozin th:มีโคลซีน
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
