Medial forebrain bundle
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| Brain: Medial forebrain bundle | ||
|---|---|---|
| Latin | fasciculus medialis telencephali | |
| NeuroNames | hier-416 | |
| MeSH | Medial+Forebrain+Bundle | |
| Dorlands/Elsevier | f_03/12356134 | |
The Medial forebrain bundle (MFB) is a bundle of axons that carries information between the ventral tegmentum and the nucleus accumbens. It is commonly accepted that the MFB is a part of the reward system, involved in the integration of reward and pleasure.
Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable. This is most likely because the medial forebrain bundle carries information ventral tegmental area (VTA) to the nucleus accumbens (nAcc or Acb). The nAcc is a recognized reward center, and activation of the pathway from the VTA to the nAcc is believed to be rewarding.
Cultural references
(2001) Bernard Werber - "L'ultime Secret" (The Ultimate Secret): Keystone of murder investigation in this book is the search for "the ultimate secret" in the name of which Fincher, apparently died of orgasmic pleasure in the arms of his mistress, was assassinated. What confirms soon the murder of the doctor-legist having taken Fincher's medial forebrain bundle during the autopsy... (http://en.wikipedia.org/wiki/Bernard_Werber#Works)
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
