Menadione
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| Menadione | |
|---|---|
| |
| IUPAC name | 2-methylnaphthalene-1,4-dione |
| Identifiers | |
| CAS number | |
| PubChem | |
| SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O |
| Properties | |
| Molecular formula | C11H8O2 |
| Molar mass | 172.18 |
| Melting point |
102 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Menadione is a polycyclic aromatic ketone, based on 1,4-naphthoquinone, with a 2-methyl substituent.
It was formerly sometimes called vitamin K3, although derivatives of naphthoquinone without the sidechain in the 3-position cannot exert all the functions of the K vitamins. Menadione is a vitamin precursor of K2 which utilizes alkylation in the liver to yield menaquinones (MK-n, n=1-13; K2 vitamers), and hence, is better classified as a provitamin.
Despite the fact that it can serve as a precursor to various types of vitamin K, menadione is generally not used as a nutritional supplement. Large doses of menadione have been reported to cause adverse outcomes including hemolytic anemia due to G6PD deficiency, neonatal brain or liver damage, or neonatal death in some cases. Moreover, menadione supplements have been banned by the FDA because of their high toxicity. Menadione has been used experimentally as a chemotherapic agent for cancer, ca 1945, but has lost ground to much safer, human form, vitamin K2 vitamers. Low level menadione is still used as an inexpensive micronutrient for livestock in many countries.
Lately, menadione has been mentioned again as a treatment for cancer in conjunction with vitamin C (See "The end of cancer" by April Kirkendoll) but modern researchers and trials are investigating nontoxic K2 vitamers such as menaquinone-4[2] in conjunction with more comprehensive regimens.
See also
Antihemorrhagics (B02) | |
|---|---|
| Antifibrinolytics | amino acids (Aminocaproic acid, Tranexamic acid, Aminomethylbenzoic acid) - serpins (Aprotinin, Alfa1 antitrypsin, C1-inhibitor, Camostat) |
| Vitamin K | Phytomenadione - Menadione |
| Fibrinogen | Fibrinogen |
| Local hemostatics | Absorbable gelatin sponge - Oxidized cellulose - Tetragalacturonic acid hydroxymethylester - Adrenalone - Thrombin - Collagen - Calcium alginate - Epinephrine |
| Blood coagulation factors | IX - II - VII - X - VIII - Eptacog alfa - Nonacog alfa - Thrombin |
| Other systemic hemostatics | Etamsylate - Carbazochrome - Batroxobin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
