Mesoridazine
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| Image:Mesoridazine.png | |
| Image:Mesoridazine3d.png | |
| Mesoridazine
| |
| Systematic (IUPAC) name | |
| 10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}-2-methylsulfinyl-10H-phenothiazine | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C21H26N2OS2 |
| Mol. mass | 386.576 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 4% |
| Metabolism | Hepatic/Renal |
| Half life | 24 to 48 hours |
| Excretion | Biliary and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status |
℞ Prescription only |
| Routes | oral, intravenous |
Mesoridazine besylate (sold as Serentil) is a piperidine antipsychotic neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. It exerts its actions through blockade of central adrenergic receptors, dopamine receptors, serotonin receptors, and an anticholinergic blocking.[1] It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.
Mesoridazine partially derives its name from the prefix "Meso"[citation needed] which means "middle" which is the center of the brain called the limbic system where most dopaminergic activity takes place. The middle of the brain also contains the pineal gland and hypothalamus.
For further information see: Phenothiazine
Mesoridazine was withdrawn from the United States market in 2004.
Psycholeptics: antipsychotics (N05A) | |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine) |
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
