Mevalonate kinase

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mevalonate kinase (mevalonic aciduria)
Identifiers
Symbol	MVK
Entrez	4598
HUGO	7530
OMIM	251170
RefSeq	NM_000431
UniProt	Q03426
Other data
EC number	2.7.1.36
Locus	Chr. 12 q24

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Mevalonate kinase is an enzyme in the mevalonate pathway.

External links

• MeSH mevalonate+kinase

v • d • e Phosphotransferases/kinases (EC 2.7)
2.7.1 - OH acceptor	Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Thymidine - NAD+ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine
2.7.2 - COOH acceptor	Phosphoglycerate - Aspartate
2.7.3 - N acceptor	Creatine
2.7.4 - PO4 acceptor	Phosphomevalonate - Adenylate - Nucleoside-diphosphate
2.7.6 - P2O7	Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase
2.7.7 - nucleotidyl-	Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase
2.7.8 - other phos.	N-acetylglucosamine-1-phosphate transferase
2.7.10-11 - protein	Tyrosine - Serine/threonine-specific

v • d • e Metabolism: Ketones/mevalonate pathway/cholesterol synthesis
To HMG-CoA	Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step)
Ketogenesis	HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase
To Mevalonic acid	HMG-CoA reductase
To DMAPP	Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase
To Cholesterols	Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1
To Bile acids	Cholesterol 7 alpha-hydroxylase
see also intermediates