Mianserin

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Image:Mianserin.svg
Mianserin
Systematic (IUPAC) name
?
Identifiers
CAS number	24219-97-4
ATC code	N06AX03
PubChem	4184
Chemical data
Formula	C18H20N2
Mol. mass	264.365
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. Mianserin is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. It was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.

Mianserin blocks inhibitory α2-autoreceptors on central noradrenergic nerve endings, and so may increase the amount of noradrenaline in the synaptic cleft. It may also cause agranulocytosis and aplastic anaemia.

Mianserin has been shown to increase the lifespan of the nematode C. elegans by 30%.^{[1] [1]}

References

v • d • e Psychoanaleptics: antidepressants (N06A)
MAOIs	Iproclozide • Iproniazid • Isocarboxazid • Minaprine • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine RIMAs: Befloxatone • Brofaromine • Cimoxatone • Beta-carbolines (Harmaline) • Moclobemide
RIs	S RI SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone) N RI / A RI Atomoxetine • Maprotiline • Nisoxetine • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Protriptyline, Trimipramine, Maprotiline) D RI Medifoxamine • Phenmetrazine • Vanoxerine • TCAs (Amineptine) SN RI Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine ND RI Bupropion SND RI Brasofensine • Tesofensine • Nomifensine
SSREs	Tianeptine
AAs	Tetras (Mianserin, Mirtazapine)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .