Mitochondrial matrix

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In the mitochondrion, the matrix contains soluble enzymes that catalyze the oxidation of pyruvate and other small organic molecules.

The mitochondrial matrix also contains the mitochondria's DNA and ribosomes. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The cytosolic compartment has a water content of 3.8 μl/mg protein, while the mitochondrial matrix 0.8 μl/mg protein (Soboll S et al, in "Use of of Isolated Liver Cells and Kidney Tubules in Metabolic Studies" pg 29-40, Academic Press, New York and London). It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport.

Citric acid cycle

The citric acid cycle (or Krebs cycle or TCA cycle) takes place within the mitochondrial matrix. In this cycle, pyruvic acid generated from glycolysis is converted into acetyl coenzyme A (acetyl CoA) by losing a carbon dioxide molecule. It then combines with oxaloacetic acid to form citric acid, a six-carbon molecule. In total, it loses 2 CO₂ molecules and 4 electrons, of which 3 are accepted by NAD+ to reduce it to NADH, and the last electron accepted by FAD+ to reduce to FADH₂ in redox reactions. In the end, it regenerates oxaloacetic acid to continue the citric acid cycle. In addition, a single GTP molecule is created from the combination of GDP and a phosphate group.

Since 2 pyruvic acid molecules are formed by glycolysis, each time a cell undergoes glycolysis two turns of the citric acid cycle will occur. That means that the citric acid cycle produces a total of 6 NADH, 2 FADH2, and 2 GTP molecules.

Electron transport chain

The electron transport chain is located in the cristae of the inner mitochondrial membrane. The NADH and FADH2 produced by the citric acid cycle in the matrix release a proton and electron to regenerate NAD+ and FAD+. The proton is pulled into the intermembrane space by the energy of the electrons going through the electron transport chain. The electron is finally accepted by oxygen in the matrix. The protons return to the mitochondrial matrix through the process of chemiosmosis through the protein ATP synthase.

See also

• Matrix (biology)

v • d • e Mitochondrial enzymes and transporters
Outer membrane	Long fatty acyl CoA synthetase - Kynureninase - Monoamine oxidase
Intermembrane space	Adenylate kinase - Creatine kinase
Inner membrane	Coenzyme Q - cytochrome c reductase -Cytochrome c - Dihydroorotate dehydrogenase -Glutamate aspartate transporter - Glycerol-3-phosphate dehydrogenase - NADH dehydrogenase - Succinate dehydrogenase
Matrix	Aconitase - Aspartate transaminase - ALDH2 - Carbamoyl phosphate synthase - Citrate synthase - Fumarase - Glutamate dehydrogenase - Isocitrate dehydrogenase - Malate dehydrogenase - Ornithine transcarbamoylase - Oxoglutarate dehydrogenase - Pyruvate dehydrogenase complex - Succinyl coenzyme A synthetase
Mitochondrial DNA	Complex I (7 units) - Complex III (1 unit) - Complex IV (3 units) - ATP synthase (2 units)

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .