Murine leukemia virus
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The murine leukemia virus belongs to the gammaretroviral genus of the Retroviridae family of viruses, their hosts are vertebrates. It is a Type VI: positive sense ssRNA viruses that replicates through a DNA intermediate, reverse transcriptase.
Contents |
Structure of Virus
The virus particle consists of 65% protein, 35% lipid and 3% carbohydrate. As it is a type of retrovirus, it has a complex structure, consisting of a virus envelope which is studded with carbohydrate molecules (which originate from host cell membranes during virus exit from the host cell). The virus also has a spherical nucleocapsid which contains the nucleocapsoid. The virus is a spherical particle of approximately 90nm diameter.
Genome
The genome of the murine leukemia virus has been fully sequenced; it is a single stranded, linear, positive-sense RNA molecule of around 8000 nucleotides. The virus RNA molecule contains a 5' methylated cap structure and 3' poly-A tail. The genome codes for both structural and non-structural proteins (such as RNA-dependent DNA polymerase which is important during the reverse transcription stage).
Applications of MuLV
- Gene therapy
- Cancer studies - this virus can be used to study cancer mutagenesis.
References
RNA viruses: retroviruses | |
|---|---|
| L/S | Lentivirus (HIV, SIV, FIV) - Spumavirus (SFV, HFV) |
| A-E | Alpharetrovirus (Avian leukosis virus, Rous sarcoma virus) - Betaretrovirus (Mouse mammary tumour virus) - Gammaretrovirus (Murine leukemia virus, Abelson murine leukemia virus, Feline leukemia virus) - Deltaretrovirus (Human T-lymphotropic virus) - Epsilonretrovirus |
| Other | Endogenous retrovirus |
