Mycobacterium heidelbergense
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| Mycobacterium heidelbergense | ||||||||||||||
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| Scientific classification | ||||||||||||||
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| Mycobacterium heidelbergense Haas et al. 1998, ATCC 51253 |
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Mycobacterium heidelbergense
Description
Gram-positive, and nonmotile acid-fast coccobacilli (0.5-0.8µm x 2.0-3.0µm).
Colony characteristics
- Smooth, dome-like and nonpigmented colonies on Löwenstein-Jensen media at 35°C (0.5 -1 mm in diameter).
Physiology
- Slow growth on Löwenstein-Jensen medium at 35°C within 3-4 weeks.
- Optimal growth at a temperature range from 33°C to 35°C, but also growth at 30°C and 37°C, neither growth at 25°C nor at 45°C.
- Susceptible to isoniazid, rifampicin and ethambutol.
- Resistant to pyrazinamide and cycloserine.
Differential characteristics
- Differentiation from M. malmoense, (bearing a strong phenotypic resemblance to M. heidelbergense), by its wider range of susceptibility to antituberculous drugs, (including isoniazid), and by its inability to grow on Löwenstein-Jensen medium at 25°C.
- Differentiation of M. triplex from M. heidelbergense by its positive nitrate reduction test and by its characteristic HPLC profile (triple-mycolate pattern).
Pathogenesis
- Cervical lymphadenitis in immunocompetent patients.
- Biosafety level not known
Type Strain
- First isolated from a immunocompetent paediatric patient with cervical lymphadenitis with recurrent fistula formation, in Heidelberg, Germany.
Strain 2554/91 = ATCC 51253 = CIP 105424 = DSM 44471.
References
- Haas et al. 1997. A new agent of mycobacterial lymphadenitis in children: Mycobacterium heidelbergense sp. nov. J. Clin. Microbiol. 35, 3203-3209.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
