Myosin light-chain kinase
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| myosin, light polypeptide kinase
| |
| Identifiers | |
| Symbol | MYLK |
| Entrez | 4638 |
| HUGO | 7590 |
| OMIM | 600922 |
| RefSeq | NM_053025 |
| UniProt | Q15746 |
| Other data | |
| EC number | 2.7.11.18 |
| Locus | Chr. 3 qcen-q21 |
| myosin light chain kinase 2, skeletal muscle
| |
| Identifiers | |
| Symbol | MYLK2 |
| Entrez | 85366 |
| HUGO | 16243 |
| OMIM | 606566 |
| RefSeq | NM_033118 |
| UniProt | Q9H1R3 |
| Other data | |
| Locus | Chr. 20 q13.31 |
Myosin-light-chain kinase (MLCK) is a serine/threonine-specific protein kinase which phosphorylates myosin.
This protein is important in the mechanism of contraction in smooth muscle. Once there is an influx of calcium into the smooth muscle, either from the sarcoplasmic reticulum or more importantly from the extracellular space, contraction of smooth muscle fibres may begin. First the calcium will bind to Calmodulin. This binding will activate MLCK which will go on to phosphorylate the myosin light chain at serine residue 19. This will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin (through the crossbridge cycle). Since smooth muscle does not contain a troponin complex like striated muscle, this mechanism is considered the main pathway by which smooth muscle regulates contraction.
See also
External links
Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11) | |
|---|---|
| 2.7.11 | Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G - Protein kinase C (Protein kinase Mζ) - Rhodopsin - Beta adrenergic receptor - G-protein coupled receptor kinases - Ca2+/calmodulin-dependent - Myosin light-chain) - Phosphorylase - Cyclin-dependent - Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) - MAP3K - GSK-3 - AMP-activated |
| 2.7.12 | MAP2K (1, 2, 3, 4, 5, 6, 7) |
| 2.7.1.37, or unknown | Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
