N-Acetylglutamic acid

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N-Acetylglutamic acid
IUPAC name	(2S)-2-Acetamidopentanedioic acid
Other names	Acetylglutamic acid, N-Acetylglutamic acid, N-Acetyl-L-glutamic acid, N-Acetyl-Glu, Ac-Glu-OH, NAcGlu
Identifiers
CAS number	1188-37-0
PubChem	70914
SMILES	OC(=O)CC[C@H](NC(=O)C)C(=O)O
InChI	InChI=1/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10) 11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)
Properties
Molecular formula	C7H11NO5
Molar mass	189.17 g/mol
Density	1 g/cm3
Melting point	191 - 194 °C
Solubility in water	36 g/l
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

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Overview

N-Acetylglutamic acid (abbreviated NAcGlu) is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase. Arginine is the activator for this reaction.

The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase.

NAcGlu activates carbamoyl phosphate synthase in the urea cycle.

See also

• Glutamate
• Glutamic acid

External links

• Diagram at biochemj.org

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