Nafarelin

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

For patient information, click here.

Nafarelin
Systematic (IUPAC) name
?
Identifiers
CAS number	76932-56-4
ATC code	H01CA02
PubChem	?
DrugBank	APRD01129
Chemical data
Formula	C66H83N17O13
Mol. mass	1321.6344 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	2.6 to 4 hours
Excretion	renal
Therapeutic considerations
Pregnancy cat.	X
Legal status	℞-only
Routes	Nasal spray

WikiDoc Resources for Nafarelin
Articles
Most recent articles on Nafarelin Most cited articles on Nafarelin Review articles on Nafarelin Articles on Nafarelin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Nafarelin Images of Nafarelin Photos of Nafarelin Podcasts & MP3s on Nafarelin Videos on Nafarelin
Evidence Based Medicine
Cochrane Collaboration on Nafarelin Bandolier on Nafarelin TRIP on Nafarelin
Clinical Trials
Ongoing Trials on Nafarelin at Clinical Trials.gov Trial results on Nafarelin Clinical Trials on Nafarelin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Nafarelin NICE Guidance on Nafarelin NHS PRODIGY Guidance FDA on Nafarelin CDC on Nafarelin
Books
Books on Nafarelin
News
Nafarelin in the news Be alerted to news on Nafarelin News trends on Nafarelin
Commentary
Blogs on Nafarelin
Definitions
Definitions of Nafarelin
Patient Resources / Community
Patient resources on Nafarelin Discussion groups on Nafarelin Patient Handouts on Nafarelin Directions to Hospitals Treating Nafarelin Risk calculators and risk factors for Nafarelin
Healthcare Provider Resources
Symptoms of Nafarelin Causes & Risk Factors for Nafarelin Diagnostic studies for Nafarelin Treatment of Nafarelin
Continuing Medical Education (CME)
CME Programs on Nafarelin
International
Nafarelin en Espanol Nafarelin en Francais
Businness
Nafarelin in the Marketplace Patents on Nafarelin
Experimental / Informatics
List of terms related to Nafarelin

Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF.

It is normally delivered via a nasal spray.

Nafarelin acetate is marketed by Searle under the brand name Synarel.

Side effects

Side effects of nafarelin are mostly related to the low estrogen state. Side effects include hot flashes, vaginal dryness, headaches, mood changes, and decreased interest in sex. Some patients may experience acne, muscle pain, reduced breast size, and irritation of the tissue inside the nose. These side effects should disappear after stopping the medication.

v • d • e WikiDoc Research Resources for Nafarelin
Articles on Nafarelin	Most recent articles on Nafarelin • Most cited articles on Nafarelin • Review articles on Nafarelin • Articles on Nafarelin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Nafarelin	Powerpoint slides on Nafarelin • Images of Nafarelin • Photos of Nafarelin • Podcasts & MP3s on Nafarelin • Videos on Nafarelin
Evidence Based Medicine Regarding Nafarelin	Cochrane Collaboration on Nafarelin • Bandolier on Nafarelin • TRIP on Nafarelin
Cost Effectiveness of Nafarelin	Cost Effectiveness of Nafarelin
Clinical Trials Involving Nafarelin	Ongoing Trials on Nafarelin at Clinical Trials.gov • Trial results on Nafarelin • Clinical Trials on Nafarelin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Nafarelin	US National Guidelines Clearinghouse on Nafarelin • NICE Guidance on Nafarelin • NHS PRODIGY Guidance • FDA on Nafarelin • CDC on Nafarelin
Textbook Information on Nafarelin	Books and Textbook Information on Nafarelin
Pharmacology Resources on Nafarelin	Dosing of Nafarelin • Drug interactions with Nafarelin • Side effects of Nafarelin • Allergic reactions to Nafarelin • Overdose information on Nafarelin • Carcinogenicity information on Nafarelin • Nafarelin in pregnancy • Pharmacokinetics of Nafarelin •
Genetics, Pharmacogenomics, and Proteinomics of Nafarelin	Genetics of Nafarelin • Pharmacogenomics of Nafarelin • Proteomics of Nafarelin
Newstories on Nafarelin	Nafarelin in the news • Be alerted to news on Nafarelin • News trends on Nafarelin
Commentary on Nafarelin	Blogs on Nafarelin
Patient Resources on Nafarelin	Patient resources on Nafarelin • Discussion groups on Nafarelin • Patient Handouts on Nafarelin • Directions to Hospitals Treating Nafarelin • Risk calculators and risk factors for Nafarelin
Healthcare Provider Resources on Nafarelin	Symptoms of Nafarelin • Causes & Risk Factors for Nafarelin • Diagnostic studies for Nafarelin • Treatment of Nafarelin
Continuing Medical Education (CME) Programs on Nafarelin	CME Programs on Nafarelin
International Resources on Nafarelin	Nafarelin en Espanol • Nafarelin en Francais
Business Resources on Nafarelin	Nafarelin in the Marketplace • Patents on Nafarelin
Informatics Resources on Nafarelin	List of terms related to Nafarelin

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS
Progestogens: (receptor)	PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone
Androgens: (receptor)	TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone
Estrogens: (receptor)	ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole
Gonadotropins: (FSHR/LHCGR)	ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone
GnRH: (receptor)	agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix

v • d • e Pituitary and hypothalamic hormones and analogues (H01)
Anterior pituitary	Adrenocorticotropic hormone (Corticotropin, Tetracosactide) - Thyrotropin - Somatropin/agonists (Somatrem, Mecasermin, Sermorelin) - other (Pegvisomant)
Posterior pituitary	Vasopressin (Desmopressin, Lypressin, Terlipressin, Ornipressin, Argipressin) - Oxytocin (Demoxytocin, Carbetocin)
Hypothalamic	gonadotropin-releasing hormones (Gonadorelin, Nafarelin, Histrelin) - antigrowth hormone (Somatostatin, Octreotide, Lanreotide) - anti-gonadotropin-releasing hormones (Ganirelix, Cetrorelix)

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .