Nelson's syndrome

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Nelson's syndrome Classification and external resources
ICD-10	E24.1
DiseasesDB	8863
eMedicine	ped/1558

WikiDoc Resources for Nelson's syndrome
Articles
Most recent articles on Nelson's syndrome Most cited articles on Nelson's syndrome Review articles on Nelson's syndrome Articles on Nelson's syndrome in N Eng J Med, Lancet, BMJ
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Powerpoint slides on Nelson's syndrome Images of Nelson's syndrome Photos of Nelson's syndrome Podcasts & MP3s on Nelson's syndrome Videos on Nelson's syndrome
Evidence Based Medicine
Cochrane Collaboration on Nelson's syndrome Bandolier on Nelson's syndrome TRIP on Nelson's syndrome
Clinical Trials
Ongoing Trials on Nelson's syndrome at Clinical Trials.gov Trial results on Nelson's syndrome Clinical Trials on Nelson's syndrome at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Nelson's syndrome NICE Guidance on Nelson's syndrome NHS PRODIGY Guidance FDA on Nelson's syndrome CDC on Nelson's syndrome
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Nelson's syndrome in the news Be alerted to news on Nelson's syndrome News trends on Nelson's syndrome
Commentary
Blogs on Nelson's syndrome
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Definitions of Nelson's syndrome
Patient Resources / Community
Patient resources on Nelson's syndrome Discussion groups on Nelson's syndrome Patient Handouts on Nelson's syndrome Directions to Hospitals Treating Nelson's syndrome Risk calculators and risk factors for Nelson's syndrome
Healthcare Provider Resources
Symptoms of Nelson's syndrome Causes & Risk Factors for Nelson's syndrome Diagnostic studies for Nelson's syndrome Treatment of Nelson's syndrome
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Nelson's syndrome en Espanol Nelson's syndrome en Francais
Businness
Nelson's syndrome in the Marketplace Patents on Nelson's syndrome
Experimental / Informatics
List of terms related to Nelson's syndrome

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Nelson's syndrome is the rapid enlargement of a pituitary adenoma that occurs after the removal of both adrenal glands.

Removal of both adrenal glands, or bilateral adrenalectomy, is an operation for Cushing's Disease. Removal of both adrenals eliminates production of cortisol, and the lack of cortisol's negative feedback can allow any preexisting pituitary adenoma to grow unchecked. Continued growth can cause mass effects due to physical compression of brain tissue, along with increased production of adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH).

The common signs and symptoms include muscle weakness and skin hyperpigmentation due to excess MSH. Nelson's syndrome is rare because bilateral adrenalectomy is now only used in extreme circumstances.

References

• Nelson D, Meakin J, Thorn G (1960). "ACTH-producing pituitary tumors following adrenalectomy for Cushing's syndrome.". Ann Intern Med 52: 560-9. PMID 14426442.

v • d • e Endocrine pathology: endocrine diseases (E00-35, 240-259)
Thyroid	Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome
Pancreas	Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome)
Parathyroid	Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)
Pituitary	Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease/Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy - Empty sella syndrome
Adrenal	Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism
Gonads	ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - testicular dysfunction (5-alpha-reductase deficiency) - testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - general (Hypogonadism, Delayed puberty, Precocious puberty)
Other	Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome

v • d • e WikiDoc Research Resources for Nelson's syndrome (Click show to right to view)
Articles on Nelson's syndrome	Most recent articles on Nelson's syndrome • Most cited articles on Nelson's syndrome • Review articles on Nelson's syndrome • Articles on Nelson's syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Nelson's syndrome	Powerpoint slides on Nelson's syndrome • Images of Nelson's syndrome • Photos of Nelson's syndrome • Podcasts & MP3s on Nelson's syndrome • Videos on Nelson's syndrome
Evidence Based Medicine Regarding Nelson's syndrome	Cochrane Collaboration on Nelson's syndrome • Bandolier on Nelson's syndrome • TRIP on Nelson's syndrome
Cost Effectiveness of Nelson's syndrome	Cost Effectiveness of Nelson's syndrome
Clinical Trials Involving Nelson's syndrome	Ongoing Trials on Nelson's syndrome at Clinical Trials.gov • Trial results on Nelson's syndrome • Clinical Trials on Nelson's syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Nelson's syndrome	US National Guidelines Clearinghouse on Nelson's syndrome • NICE Guidance on Nelson's syndrome • NHS PRODIGY Guidance • FDA on Nelson's syndrome • CDC on Nelson's syndrome
Textbook Information on Nelson's syndrome	Books and Textbook Information on Nelson's syndrome
Pharmacology Resources on Nelson's syndrome	Dosing of Nelson's syndrome • Drug interactions with Nelson's syndrome • Side effects of Nelson's syndrome • Allergic reactions to Nelson's syndrome • Overdose information on Nelson's syndrome • Carcinogenicity information on Nelson's syndrome • Nelson's syndrome in pregnancy • Pharmacokinetics of Nelson's syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Nelson's syndrome	Genetics of Nelson's syndrome • Pharmacogenomics of Nelson's syndrome • Proteomics of Nelson's syndrome
Newstories on Nelson's syndrome	Nelson's syndrome in the news • Be alerted to news on Nelson's syndrome • News trends on Nelson's syndrome
Commentary on Nelson's syndrome	Blogs on Nelson's syndrome
Patient Resources on Nelson's syndrome	Patient resources on Nelson's syndrome • Discussion groups on Nelson's syndrome • Patient Handouts on Nelson's syndrome • Directions to Hospitals Treating Nelson's syndrome • Risk calculators and risk factors for Nelson's syndrome
Healthcare Provider Resources on Nelson's syndrome	Symptoms of Nelson's syndrome • Causes & Risk Factors for Nelson's syndrome • Diagnostic studies for Nelson's syndrome • Treatment of Nelson's syndrome
Continuing Medical Education (CME) Programs on Nelson's syndrome	CME Programs on Nelson's syndrome
International Resources on Nelson's syndrome	Nelson's syndrome en Espanol • Nelson's syndrome en Francais
Business Resources on Nelson's syndrome	Nelson's syndrome in the Marketplace • Patents on Nelson's syndrome
Informatics Resources on Nelson's syndrome	List of terms related to Nelson's syndrome

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .