Neonatal hemochromatosis
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Neonatal Hemochromatosis is a rare and severe liver disease. It's characteristics are similar to hereditary hemochromatosis, where iron deposition causes damage to the liver and other organs and tissues.
The causes of neonatal hemochromatosis are still unknown, however recent research has led to the hypothesis that it is an alloimmune disease (see autoimmunity). Evidence supporting this hypothesis includes the high recurrence rate within sibships (>80%).
Effective treatment of the disease has been confined to liver transplants. An antioxidant chelation cocktail has also been reported as having some success though its effectiveness cannot be confirmed.
Based on the alloimmune cause hypothesis, a new treatment involving high-dose immunoglobulin to pregnant mothers who have had a previous pregnancy with a confirmed neonatal hemochromatosis outcome, has provided very encouraging results.[1]
References
External links
- American Hemochromatosis Society
- International Bioiron Society
- Canadian Hemochromatosis Society
- Haemochromatosis page
- "The Bronze Killer" Mary Warder's book on Hemochromatosis
- Causes of Haemochromatosis
- Iron Toxicity, What you don't know
- Andrews N (1999). "Disorders of iron metabolism". New England Journal of Medicine 341 (26): 1986-95. PMID 10607817. link
- Haemochromatosis Society, UK
- Haemochromatosis Society Australia Inc
- Hemachromatosis page at the National Center for Biotechnology Information
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
