Neural tube defect

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Neural tube defect Classification and external resources
OMIM	182940
DiseasesDB	8926
eMedicine	neuro/244  ped/2805
MeSH	D009436

A neural tube defect will occur in human embryos if there is an interference with the closure of the neural tube occurs around the 28th day after fertilization. The incidence of neural tube defects is 2.6 in 1,000 worldwide. ^{[citation needed]}

Causes

Pregnant women taking medication for epilepsy have a higher chance of having a child with a neural tube defect. Research has shown that women with folic acid deficiencies also have a higher chance of having a child with a neural tube defect, but this is only one factor. Taking folic acid does not completely negate the risk of neural tube problems, but it does significantly reduce the risk.

Prevention

In Canada, mandatory fortification of selected foods with folic acid has been shown to reduce the incidence of neural tube defects by 46%^[1].

Women who are or could become pregnant are advised to take daily supplements of folic acid, unless their dietary intake of this nutrient is normally high.

Detection

Neural tube defects may be detected by a variety of methods, including some prenatal screening tests and medical imaging. Often, these defects are apparent at birth, but occult defects may be not diagnosed until much later in life.

Types of neural tube defects

• Anencephaly
• Encephalocele
• Spina bifida including myelomeningocele and others

References

See also

• Neurulation

External links

• MeSH Neural+Tube+Defects
• MedlinePlusde:Neuralrohrdefekt

he:פגמים בתעלה העיצבית nl:Neuraalbuisdefect

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .