Niclosamide
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| Image:Niclosamide.png | |
| Niclosamide
| |
| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | P02 |
| PubChem | |
| Chemical data | |
| Formula | C13H8Cl2N2O4 |
| Mol. mass | 327.119 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide.
It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.
It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
Niclosamide molecules are lethal to tapeworms upon contact.
Side effects
The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis. Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.
Mechanism of action
According to an article in Nature,[1] niclosamide uncouples oxidative phosphorylation in the tapeworm.
References
- Taber, Clarence Wilbur; Venes, Donald; Thomas, Clayton L. (2001). Taber's cyclopedic medical dictionary. Philadelphia: F.A.Davis Co.
- Additional Medication Information:Medline
- http://www.drugs.com/cons/Niclosamide.html
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
