Noradrenergic and specific serotonergic antidepressant

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Noradrenergic and specific serotonergic antidepressants (abbreviated: NaSSAs) are a relatively new class of antidepressants.^[1] They are thought to work by blocking presynaptic alpha-2 adrenergic receptors that normally inhibit the release of the neurotransmitters norepinephrine (noradrenaline) and serotonin. This results in increases in both noradrenergic and specific serotonergic transmission.

Examples of NaSSAs include:

• Mirtazapine (Remeron®, Zispin®, Avanza®, Norset®, Remergil®, Axit®)

NaSSAs are said to have fewer side effects than tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) while being equally effective. In particular, it is said that the sexual dysfunction that is a relatively common side effect of SSRIs occurs significantly less often during treatment with Mirtazapine.^[1]

See also

• Clinical depression

References

de:NaSSA

v • d • e Psychoanaleptics: antidepressants (N06A)
MAOIs	Iproclozide • Iproniazid • Isocarboxazid • Minaprine • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine RIMAs: Befloxatone • Brofaromine • Cimoxatone • Beta-carbolines (Harmaline) • Moclobemide
RIs	S RI SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone) N RI / A RI Atomoxetine • Maprotiline • Nisoxetine • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Protriptyline, Trimipramine, Maprotiline) D RI Medifoxamine • Phenmetrazine • Vanoxerine • TCAs (Amineptine) SN RI Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine ND RI Bupropion SND RI Brasofensine • Tesofensine • Nomifensine
SSREs	Tianeptine
AAs	Tetras (Mianserin, Mirtazapine)

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .