OKT3

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It has been suggested that this article or section be merged with Muromonab-CD3. (Discuss)

OKT3 ( also called muromonab) is an immunosuppressant drug given to reduce acute rejection in transplant patients. A major milestone in the prevention of acute allograft rejection was achieved with the development of the mAb OKT3, the first mAb to be approved for clinical use in humans. OKT3 is a murine monoclonal IgG2a antibody that reacts with the T cell receptor-CD3 complex (specifically the epsilon chain of the T lymphocyte antigen Receptor) on the surface of circulating human T cells.[13] The T cell has 2 molecules on its surface which function primarily in antigen recognition. These antigen recognition structures are associated with 3 polypeptide chains (the CD-3 complex). The CD-3 complex transduces the signal for the T cell to react to the foreign antigen, proliferate, and attack the foreign matter. OKT3 is a monoclonal antibody that specifically reacts with the T-3 complex by blocking the function of T cells.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .