Obestatin

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ghrelin/obestatin preprohormone
Identifiers
Symbol	GHRL
Entrez	51738
HUGO	18129
OMIM	605353
RefSeq	NM_016362
UniProt	Q9UBU3
Other data
Locus	Chr. 3 p26-p25

Obestatin is a hormone that is produced in the cells lining the stomach and small intestine of several mammals including humans; it drastically reduces appetite in mice and is expected to do the same in humans.

Research carried out at the Stanford University School of Medicine in 2005 identified the new hormone with a bioinformatics approach by computer search of the sequenced genomes of several organisms.

Obestatin is a peptide hormone - a relatively small protein. It is encoded by the same gene that also encodes ghrelin, a peptide hormone that increases appetite. The protein produced by that gene breaks into two smaller peptides, ghrelin and obestatin. The purpose of this mechanism remains unclear, however it explains earlier findings, namely that removing the ghrelin gene from mice did not significantly reduce their appetite.

Obestatin might be developed into a drug against obesity, however it would have to be delivered as a nasal spray, injection, or transdermal patch as the peptide is destroyed by stomach acids. Rights to commercial use of the hormone lie with Johnson & Johnson which sponsored the research.

See also

• ghrelin
• nesfatin-1

References

• Holst B, Egerod KL, Schild E, et al (2007). "GPR39 signaling is stimulated by zinc ions but not by obestatin". Endocrinology 148 (1): 13-20. doi:10.1210/en.2006-0933. PMID 16959833.
• Stanford Scientists' Discovery of Hormone Offers Hope for Obesity Drug, Stanford School of Medicine Press release, 10 November 2005
• Denise Grady: "In Study, Hormone Reduced Appetite in Mice", The New York Times, 11 November 2005
• Zhang JV, Ren PG, Avsian-Kretchmer O, et al (2005). "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science 310 (5750): 996-9. doi:10.1126/science.1117255. PMID 16284174.

External links

• MeSH human obestatin, humande:Obestatin

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .