Octanol
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| Octanol | |
|---|---|
| Image:1-Octanol.png | |
| IUPAC name | 1-octanol |
| Other names | capryl alcohol octyl alcohol |
| Identifiers | |
| CAS number | |
| SMILES | CCCCCCCCO |
| Properties | |
| Molecular formula | C8H18O |
| Molar mass | 130.23 g/mol |
| Density | 0.824 g/cm3 |
| Melting point |
-16 °C |
| Boiling point |
195 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Octanol is a straight chain fatty alcohol with eight carbon atoms and the molecular formula CH3(CH2)7OH. Although the term octanol usually refers exclusively to the primary alcohol 1-octanol, there are other less common isomers of octanol such as the secondary alcohols 2-octanol, 3-octanol and 4-octanol.
Octanol occurs naturally in the form of esters in some essential oils. The primary use of octanol is in the manufacture of various esters (both synthetic and naturally occurring), such as octyl acetate, which are used in perfumery and flavors. Other uses include experimental medical applications utilizing octanol to control certain types of involuntary tremors.[1]
Water/ octanol partitioning
Octanol and water are immiscible. The distribution of a compound between water and octanol is used to calculate the partition coefficient 'P' of that molecule (often expressed as its logarithm to the base 10, log P). Water/ octanol partitioning is a good approximation of the partitioning between the cytosol and lipid membranes of living systems.[citation needed]
Many dermal absorption models consider the stratum corneum/ water partition coefficient to be well approximated by a function of the water/ octanol partition coefficient of the form [1]:
- log(Ksc / w) = a + blog(Kw / o)
Where a and b are constants,Ksc / w is the stratum corneum/ water partition coefficient, andKo / w is the water/ octanol partition coefficient. The values of a and b vary between papers, but Cleek & Bunge [1] have reported the values a=0, b=0.74.
References
Alcohols | |
|---|---|
| Primary alcohols | Methanol • Ethanol • Propan-1-ol • Butanol • Isobutanol • 1-Pentanol • 1-Hexanol • 1-Heptanol • Octanol • Nonanol • Decanol • Dodecanol • 1-Tetradecanol • Cetyl alcohol • Stearyl alcohol |
| Secondary alcohols | Isopropyl alcohol • 2-Butanol • 2-Hexanol |
| Tertiary alcohols | tert-Butanol |
it:1-ottanolo nl:1-octanol ja:オクタノール
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
