Oncogenesis

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Oncogenesis

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Overview

Oncogenesis is the process of malignant transformation leading to the formation of a tumor (tumorigenesis). It is characterized by a progression of changes on cellular and genetic level that ultimately reprogram a cell to undergo uncontrolled cell division, thus forming a malignant mass.

Oncovirinae, retroviruses which contain an onc gene, are categorized as oncogenic because they trigger the growth of tumorous tissues in the host. This process is also referred to as viral transformation.

See also

  • carcinogen a substance, radionuclide or radiation directly involved in the promotion of cancer.
  • mutagen a physical or chemical agent that changes the genetic information of an organism.
  • teratogen
  • oncogene a modified gene believed to cause cancer.

References

Hornberg, J., Binder, B., Bruggeman, F., Schoeber, B., Heinrich, R., Westerhoff, H., "Control of MAPK signalling: from complexity to what really matters", Oncogene, Vol. 24, pp 5533-5542, (published online 20June2005).

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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