Overlap syndrome
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An overlap syndrome is an autoimmune disease in which the patient presents with symptoms of two or more diseases. As much as 25% of all patients with connective tissue disease show signs of an overlap syndrome. Examples of overlap syndromes are MCTD and scleromyositis, but the exact diagnosis depends from which diseases the patient shows symptoms. In overlap syndromes features of systemic lupus erythematosus (SLE), systemic sclerosis, polymyositis, dermatomyositis, rheumatoid arthritis (RA) and Sjögren's syndrome are found most commonly. [1]
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

