Oxycodone drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884

List of drug interactions


Skeletal muscle relaxants

Use with CNS Depressants

Use with CNS Depressants

Complete List of Drug Interactions







Skeletal muscle relaxants

Opioid analgesics, including OxyContin®, may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Return to top

Use with CNS Depressants

OxyContin, like all opioid analgesics, should be started at 1/3 to 1/2 of the usual dosage in patients who are concurrently receiving other central nervous system depressants including sedatives or hypnotics, general anesthetics, phenothiazines, centrally acting anti-emetics, tranquilizers, and alcohol because respiratory depression, hypotension, and profound sedation or coma may result. No specific interaction between oxycodone and monoamine oxidase inhibitors has been observed, but caution in the use of any opioid in patients taking this class of drugs is appropriate. Return to top

Complete List of Drug Interactions

Roxicet is a multi-ingredient drug consisting of:

Acetaminophen Drug Interactions

Major Interactions

Moderate Interactions

Minor Interactions

Oxycodone Drug Interactions

Major Interactions

Moderate Interactions