Pamaquine
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| Image:Pamaquine.svg | |
| Pamaquine
| |
| Systematic (IUPAC) name | |
| N,N-diethyl-N'-(6-methoxyquinolin-8-yl)pentane- 1,4-diamine | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C19H29N3O |
| Mol. mass | 315.453 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria. It is closely related to primaquine.
History
Pamaquine was the first synthetic antimalarial drug.
Adverse effects
Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Patients should therefore always be screened for G6PD deficiency prior to being prescribed pamaquine.
Uses
Pamaquine is effective against the hypnozoites of the relapsing malarias (P. vivax and P. ovale); and unlike primaquine, it is also very effective against the erythrocytic stages of all four human malarias. One small clinical trial of pamaquine as a causal prophylactic was disappointing[1] (whereas primaquine is an extremely effective causal prophylactic).
Dosing
60 mg once daily for 14–21 days.
When treating Plasmodium vivax, an initial course of chloroquine is unnecessary.
Synonyms
- Plasmaquine
References
Antiprotozoals: Antimalarial drugs (P01B) | |
|---|---|
| Aminoquinolines | 4-Aminoquinoline (Amodiaquine, Chloroquine, Hydroxychloroquine) • 8-Aminoquinoline (Pamaquine, Primaquine) |
| Methanolquinolines | Mefloquine • Quinine |
| Biguanides | Proguanil • Cycloguanil embolate |
| Diaminopyridines | Pyrimethamine |
| Artemisinin derivatives | Artemisinin • Artemether • Artesunate • Artenimol • Arteether/Artemotil |
| Others | Halofantrine • Lumefantrine |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
