Pancreatic polypeptide
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| pancreatic polypeptide
| |
| Identifiers | |
| Symbol | PPY |
| Entrez | 5539 |
| HUGO | 9327 |
| OMIM | 167780 |
| RefSeq | NM_002722 |
| UniProt | P01298 |
| Other data | |
| Locus | Chr. 17 p11.1-qter |
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Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.
The function of PP is unknown, but effects on hepatic glycogen levels and gastrointestinal secretions have been suggested. For instance, it it thought to be a a cholecystokinin antagonist, and thus suppress the pancreatic secretion and stimulate gastric secretion.
Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.
Differential Diagnosis
Increased
- Advanced Age
- Gastrinoma
- Insulinoma
- PPoma
- VIPoma
External links
- Physiology at MCG 6/6ch2/s6ch2_25
- MeSH Pancreatic+polypeptide
- BBC Hope over 'obesity-busting gum' 15 January, 2007
Endocrine system > Pancreas - Islets of Langerhans | |
|---|---|
| A/B | alpha cell (glucagon) • beta cell (insulin) |
| Other | delta cell (somatostatin) • PP cell (pancreatic polypeptide) • epsilon cell (ghrelin) |
Peptides: neuropeptides | |
|---|---|
| Hypothalamic | Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) |
| Gastrointestinal hormones | Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide |
| Other hormones | Vasopressin - Calcitonin - |
| Other | Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
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