Pentagastrin
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| Image:Pentagastrin.png | |
| Pentagastrin
| |
| Systematic (IUPAC) name | |
| 4-(1-carbamoyl-2-phenyl-ethyl)amino-3-[2-[3-(1H-indol-3-yl)-2- [3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino- 4-methylsulfanyl-butanoyl]amino-4-oxo-butanoic acid | |
| Identifiers | |
| CAS number | |
| ATC code | V04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C37H49N7O9S |
| Mol. mass | 767.893 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 10 minutes or less |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it causes panic attacks.
Pentagstrin's IUPAC chemical name is "L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl".
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
