Phosphatidylcholine
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Overview
Phosphatidylcholine or Polyenylphosphatidylcholine[2] is a phospholipid that is the major component of a phosphatide fraction, which may be isolated from either egg yolk (in Greek lekithos - λεκιθος) or soy beans from which it is mechanically or chemically extracted using hexane.
It is such a major component of lecithin, that, in some contexts, the terms are sometime used as synonyms. However, lecithin extract consists of a mixture of phosphatidylcholine and other compounds. It is also used along with Sodium taurocholate for simulating fed- and fasted-state biorelevant media in dissolution studies of highly-lipophilic drugs. Phosphatidylcholine is a major constituent of cell membranes.
Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid (PA), releasing the soluble choline headgroup into the cytosol.
Some medical researchers are experimenting with using Phosphatidylcholine in a type of injection that will break down fat cells; to be used as an alternative to liposuction known as Injection lipolysis.
See also
Additional images
Choline metabolism.png
Choline metabolism |
Phosphatidate2.png
|
External links
http://www.kvue.com/news/top/stories/110507kvuelipodissolve-mm.1e0189bdb.html
Lipids: phospholipids | |
|---|---|
| Glycerol backbone (Glycerophospholipids/ Phosphoglycerides) | Phosphatidyl-: -ethanolamine/cephalin - -choline/lechithin (dipalmitoyl-) - -serine - -glycerol - -inositol (glyco-)
phosphatidylinositol phosphates: PIP1 - PIP2 (3,4, 3,5, 4,5) - PIP3 Ether lipids: Plasmalogen (Platelet-activating factor) |
| Sphingosine backbone | Sphingomyelin |
Cell signaling: lipid signaling |
|---|
| Phospholipase - PIP2 - DAG - IP3 - IP3 receptor |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
