Phosphatidylinositol 3-phosphate

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Phosphatidylinositol 3-phosphate
Image:Phosphatidylinositol-3-phosphate.jpg
Other names	sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate
Molecular formula	C11H20O16P2
Molar mass	470.214
PubChem	6857403
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Phosphatidylinositol 3-phosphate (PtdIns3P) is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on Phosphatidylinositol.

PtdIns3P is dephophosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring.

The FYVE domain, and the PX domain in a number of proteins binds to PtdIns3P include those in SNX1, Hrs, and EEA1.

The majority of PtdIns3P appears to be constitutively synthesised by the class III PI 3-kinase, Vps34 at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3P, their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3P may be synthesised upon cell stimulation.

PtdIns3P in cell membranes helps to recruit a range of proteins, many of which are involved in protein trafficking.