Photopheresis
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In medicine, photopheresis is a form of apheresis in which blood is treated with photoactivable drugs which are then activated with ultraviolet light.
Photopheresis is currently standard FDA-approved therapy for cutaneous T-cell lymphoma. In this procedure, buffy coat (WBC + platelets) is separated from whole blood, chemically treated with 8-Methoxypsoralen (instilled into collection bag or given per os in advance), exposed to ultraviolet light, and returned to the patient. 8-Methoxypsoralen irreversibly binds covalently to both strands of the DNA of nucleated cells following photoactivation. The photochemically damaged T-cells returned to the patient appear to induce cytotoxic effect on T-cell formation. The mechanism of such “antitumor” action has not been elucidated. Minimal observed side effects for patients receiving photopheresis include hypotension and syncope resulting from volume shifts during leukapheresis phase of treatment. Photopheresis is also used as an experimental treatment in patients with cardiac, pulmonary and renal allograft rejection; autoimmune diseases, ulcerative colitis.
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
