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Overview
Pick's disease has two meanings that are often confused:
1) Pathology: Neurologists currently use the term "Pick's disease" to mean specifically one of the pathological subtypes of frontotemporal lobar degeneration (FTLD). The pathological hallmark of Pick's disease are Pick bodies. These are spherical cytoplasmic inclusions found within neurons in affected portions of the brain.[2] They cause neurons to swell, taking on a "ballooned" appearance. Pick bodies contain the protein Tau, and hence the disease is also referred to as a tauopathy (along with progressive supranuclear palsy, corticobasal degeneration, and others).
2) Syndrome: Pick's disease is also the old name for the clinical syndrome frontotemporal dementia (FTD). Some neurologists now avoid this use of the term, however, because it is not possible to distinguish between FTD caused by Pick's disease pathology (definition 1) and other FTLD processes prior to autopsy. However, it is important to note that a number of support groups for families of patients with frontotemporal dementia continue to use the name "Pick's disease" in their titles.
Note: This confusion has led some neurologists to suggest other names for FTLD. The most prominent is perhaps Kertesz' suggestion of the term "Pick Complex" to encompass not only the clinical syndromes associated with FTLD, but also the overlapping pathologic processes of corticobasal degeneration and progressive supranuclear palsy.
For more information on Pick's Disease, see the article on the pathologic process of frontotemporal lobar degeneration (FTLD) and its related clinical syndromes of frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.
References
External links
| WHO ICD-10 mental and behavioural disorders (F · 290–319) |
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| Neurological/symptomatic | Dementia (Alzheimer's disease, multi-infarct dementia, Pick's disease, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, AIDS dementia complex, Frontotemporal dementia) · Delirium · Post-concussion syndrome |
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| Psychoactive substance | Intoxication (drunkenness) · Physical dependence (alcohol dependence, opioid dependency, cocaine dependence) · Withdrawal (benzodiazepine withdrawal, delirium tremens) · Amnesic: (Korsakoff's syndrome) |
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| Psychotic disorder | Schizophrenia (disorganized schizophrenia) · Schizotypal personality disorder · Delusional disorder · Folie à deux · Schizoaffective disorder |
|---|
| Mood (affective) | Mania · Bipolar disorder · Clinical depression · Cyclothymia · Dysthymia |
|---|
Neurotic, stress-related
and somatoform | Agoraphobia · Anxiety disorder · Panic disorder · Generalized anxiety disorder · Social Anxiety Disorder · OCD · Acute stress reaction · PTSD · Adjustment disorder · Conversion disorder (Ganser syndrome) · Somatoform disorder · Somatization disorder · Neurasthenia |
|---|
Physiological/physical
behavioural | Eating disorder (anorexia nervosa, bulimia nervosa) · Sleep disorder (dyssomnia, insomnia, hypersomnia, parasomnia, night terror, nightmare) · Sexual dysfunction (erectile dysfunction, premature ejaculation, vaginismus, dyspareunia, hypersexuality) · Postpartum depression |
|---|
Adult personality
and behaviour | Personality disorder · Passive-aggressive behavior · Kleptomania · Trichotillomania · Voyeurism · Factitious disorder · Munchausen syndrome · Ego-dystonic sexual orientation |
|---|
| Mental retardation | Mental retardation |
|---|
Psychological development
(developmental disorder) | Specific: speech and language (expressive language disorder, aphasia, expressive aphasia, receptive aphasia, Landau-Kleffner syndrome, lisp) · Scholastic skills (dyslexia, dysgraphia, Gerstmann syndrome) · Motor function (developmental dyspraxia)
Pervasive: Autism · Rett syndrome · Asperger syndrome |
|---|
Behavioural and emotional,
childhood and adolescence onset | ADHD · Conduct disorder · Oppositional defiant disorder · Separation anxiety disorder · Selective mutism · Reactive attachment disorder · Tic disorder · Tourette syndrome · Speech (stuttering · cluttering) |
|---|
| Pathology of the nervous system, primarily CNS (G00-G47, 320-349) |
|---|
Inflammatory diseases
of the CNS | Meningitis (Arachnoiditis) - Encephalitis - Myelitis - Encephalomyelitis (Acute disseminated) - Tropical spastic paraparesis |
|---|
Systemic atrophies
primarily affecting the CNS | Huntington's
Spinocerebellar ataxia (Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia)
Spinal muscular atrophy: Werdnig-Hoffman - Kugelberg-Welander - Fazio Londe - MND (ALS, PMA, PBP, PP, PLS) |
|---|
Extrapyramidal and
movement disorders | Parkinson's disease - Neuroleptic malignant syndrome - Postencephalitic parkinsonism - Pantothenate kinase-associated neurodegeneration - Progressive supranuclear palsy - Striatonigral degeneration
Dystonia/Dyskinesia (Spasmodic torticollis, Meige's, Blepharospasm)
Essential tremor - Myoclonus - Lafora
Chorea (Choreoathetosis) - Restless legs - Stiff person |
|---|
Other degenerative /
demyelinating diseases | Alzheimer's - Pick's - Alpers' - Dementia with Lewy bodies - Leigh's
demyelinating: Multiple sclerosis - Devic's - Central pontine myelinolysis - Transverse myelitis |
|---|
| Seizure/epilepsy | Focal (Simple partial, Complex partial) - Generalised (Tonic-clonic, Absence, Atonic, Benign familial neonatal)
Lennox-Gastaut - West - Epilepsia partialis continua - Status epilepticus (Complex partial status epilepticus) |
|---|
| Headache | Migraine (Familial hemiplegic) - Cluster - Vascular - Tension |
|---|
| Vascular | Transient ischemic attack (Amaurosis fugax, Transient global amnesia)
Cerebrovascular disease (MCA, ACA, PCA, Foville's, Millard-Gubler, Lateral medullary, Weber's, Lacunar stroke) |
|---|
| Sleep disorders | Insomnia - Hypersomnia - Sleep apnea (Ondine's curse) - Narcolepsy - Cataplexy - Kleine-Levin - Circadian rhythm sleep - Delayed sleep phase - Advanced sleep phase |
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| Other | Intracranial hypertension: Hydrocephalus (Normal pressure) - Idiopathic intracranial hypertension
Encephalopathy - Brain herniation - Cerebral edema - Reye's - Syringomyelia - Syringobulbia - Spinal cord compression |
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de:Morbus Pick
fr:Maladie de Pick
lb:Pick-Krankheet
nl:Ziekte van Picksv:Picks sjukdom
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
