Pirenzepine

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Pirenzepine
Systematic (IUPAC) name
11-[(4-Methylpiperazin-1yl)acetyl]6,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-6-on
Identifiers
CAS number	28797-61-7
ATC code	A02BX03
PubChem	4848
DrugBank	APRD00515
Chemical data
Formula	C19H21N5O2
Mol. mass	351.403 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Pirenzepine (marketed by Merck Marker under the trade-name Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as Muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control.^[1]

References

v • d • e Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (A02B)
H2 antagonists	Cimetidine, Famotidine, Nizatidine, Ranitidine, Roxatidine
Prostaglandins/analogues	Misoprostol, Enprostil
Proton pump inhibitors	Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole, Tenatoprazole
Other	Carbenoxolone, Sucralfate, Pirenzepine