Plakoglobin
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| junction plakoglobin
| |
| Identifiers | |
| Symbol | JUP |
| Alt. Symbols | CTNNG |
| Entrez | 3728 |
| HUGO | 6207 |
| OMIM | 173325 |
| RefSeq | NM_002230 |
| UniProt | P14923 |
| Other data | |
| Locus | Chr. 17 q21 |
Plakoglobin (gamma-catenin, was originally identified as a component of desmosomes where it can bind to the cadherin family member desmoglein I.
Plakoglobin also associates with classical cadherins such as E-cadherin and in that context it was called gamma-catenin.
Plakoglobin is O-glycosylated near its N-terminal destruction box.
See also
External links
References
1: Cowin P, Kapprell HP, Franke WW, Tamkun J, Hynes RO. Plakoglobin: a protein common to different kinds of intercellular adhering junctions.Cell. 1986 Sep 26;46(7):1063-73.
2: Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4027-31.
3: Mathur M, Goodwin L, Cowin P. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. J Biol Chem. 1994 May 13;269(19):14075-80.
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Proteins of the cytoskeleton | |
|---|---|
| Microfilaments | Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein |
| Intermediate filaments | type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) |
| Microtubules | Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin |
| Catenins | Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin |
| Nonhuman | Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) |
| Other | APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
