Plasmin

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Plasminogen
PDB rendering based on 1b2i.
Identifiers
Symbol(s)	PLG; DKFZp779M0222
External IDs	OMIM: 173350 MGI: 97620 Homologene: 55452
Gene ontology Molecular Function: • plasmin activity • calcium ion binding • protein binding • peptidase activity Cellular Component: • extracellular space Biological Process: • proteolysis • apoptosis • induction of apoptosis • blood coagulation • negative regulation of cell proliferation • negative regulation of angiogenesis • tissue regeneration • fibrinolysis • negative regulation of blood vessel endothelial cell migration • myoblast differentiation • muscle maintenance
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5340	18815
Ensembl	ENSG00000122194	ENSMUSG00000059481
Uniprot	P00747	Q3V1T9
Refseq	NM_000301 (mRNA) NP_000292 (protein)	NM_008877 (mRNA) NP_032903 (protein)
Location	Chr 6: 161.04 - 161.09 Mb	Chr 17: 12.22 - 12.26 Mb
Pubmed search	[1]	[2]

WikiDoc Resources for Plasmin
Articles
Most recent articles on Plasmin Most cited articles on Plasmin Review articles on Plasmin Articles on Plasmin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Plasmin Images of Plasmin Photos of Plasmin Podcasts & MP3s on Plasmin Videos on Plasmin
Evidence Based Medicine
Cochrane Collaboration on Plasmin Bandolier on Plasmin TRIP on Plasmin
Clinical Trials
Ongoing Trials on Plasmin at Clinical Trials.gov Trial results on Plasmin Clinical Trials on Plasmin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Plasmin NICE Guidance on Plasmin NHS PRODIGY Guidance FDA on Plasmin CDC on Plasmin
Books
Books on Plasmin
News
Plasmin in the news Be alerted to news on Plasmin News trends on Plasmin
Commentary
Blogs on Plasmin
Definitions
Definitions of Plasmin
Patient Resources / Community
Patient resources on Plasmin Discussion groups on Plasmin Patient Handouts on Plasmin Directions to Hospitals Treating Plasmin Risk calculators and risk factors for Plasmin
Healthcare Provider Resources
Symptoms of Plasmin Causes & Risk Factors for Plasmin Diagnostic studies for Plasmin Treatment of Plasmin
Continuing Medical Education (CME)
CME Programs on Plasmin
International
Plasmin en Espanol Plasmin en Francais
Businness
Plasmin in the Marketplace Patents on Plasmin
Experimental / Informatics
List of terms related to Plasmin

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Overview

Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, most notably fibrin clots. The degradation of fibrin is termed fibrinolysis.

Functions

It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).

Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.

Pathology

Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.

Further reading

External links

• MeSH Plasmin

v • d • e Proteins: coagulation
Coagulation factors	intrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein
Inhibitors	Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI
Fibrinolysis	Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI

v • d • e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive system	Enteropeptidase - Trypsin - Chymotrypsin - Elastase (Neutrophil, Pancreatic)
Complement system	Factor B - Factor D - Factor I - MASP (MASP1, MASP2) - C3-convertase
Coagulation	factors: Thrombin - Factor VIIa - Factor IXa - Factor Xa - Factor XIa - Factor XIIa - Kallikrein (PSA) fibrinolysis: Plasmin - Tissue plasminogen activator - Urinary plasminogen activator
Immune system	Chymase - Granzyme - Tryptase - Proteinase 3/Myeloblastin
Venombin	Ancrod - Batroxobin
Other	Acrosin - Pronase - Proprotein convertases (1, 2) - Subtilisin/Furin - Streptokinase - Prolyl endopeptidase

v • d • e Globulins: beta globulins
Angiostatin - Haemopexin - Beta-2 microglobulin - Factor H - Plasminogen - Properdin - Sex hormone binding globulin - Transferrin

v • d • e WikiDoc Research Resources for Plasmin (Click show to right to view)
Articles on Plasmin	Most recent articles on Plasmin • Most cited articles on Plasmin • Review articles on Plasmin • Articles on Plasmin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Plasmin	Powerpoint slides on Plasmin • Images of Plasmin • Photos of Plasmin • Podcasts & MP3s on Plasmin • Videos on Plasmin
Evidence Based Medicine Regarding Plasmin	Cochrane Collaboration on Plasmin • Bandolier on Plasmin • TRIP on Plasmin
Cost Effectiveness of Plasmin	Cost Effectiveness of Plasmin
Clinical Trials Involving Plasmin	Ongoing Trials on Plasmin at Clinical Trials.gov • Trial results on Plasmin • Clinical Trials on Plasmin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Plasmin	US National Guidelines Clearinghouse on Plasmin • NICE Guidance on Plasmin • NHS PRODIGY Guidance • FDA on Plasmin • CDC on Plasmin
Textbook Information on Plasmin	Books and Textbook Information on Plasmin
Pharmacology Resources on Plasmin	Dosing of Plasmin • Drug interactions with Plasmin • Side effects of Plasmin • Allergic reactions to Plasmin • Overdose information on Plasmin • Carcinogenicity information on Plasmin • Plasmin in pregnancy • Pharmacokinetics of Plasmin •
Genetics, Pharmacogenomics, and Proteinomics of Plasmin	Genetics of Plasmin • Pharmacogenomics of Plasmin • Proteomics of Plasmin
Newstories on Plasmin	Plasmin in the news • Be alerted to news on Plasmin • News trends on Plasmin
Commentary on Plasmin	Blogs on Plasmin
Patient Resources on Plasmin	Patient resources on Plasmin • Discussion groups on Plasmin • Patient Handouts on Plasmin • Directions to Hospitals Treating Plasmin • Risk calculators and risk factors for Plasmin
Healthcare Provider Resources on Plasmin	Symptoms of Plasmin • Causes & Risk Factors for Plasmin • Diagnostic studies for Plasmin • Treatment of Plasmin
Continuing Medical Education (CME) Programs on Plasmin	CME Programs on Plasmin
International Resources on Plasmin	Plasmin en Espanol • Plasmin en Francais
Business Resources on Plasmin	Plasmin in the Marketplace • Patents on Plasmin
Informatics Resources on Plasmin	List of terms related to Plasmin

de:Plasmin

it:Plasmina ja:プラスミン

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .