Prostaglandin E synthase

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prostaglandin E synthase
Identifiers
Symbol	PTGES
Alt. Symbols	MGST1L1
Entrez	9536
HUGO	9599
OMIM	605172
RefSeq	NM_004878
UniProt	O14684
Other data
Locus	Chr. 9 q34.3

prostaglandin E synthase 2
Identifiers
Symbol	PTGES2
Alt. Symbols	C9orf15
Entrez	80142
HUGO	17822
OMIM	608152
RefSeq	NM_198939
UniProt	Q9H7Z7
Other data
Locus	Chr. 9 q34.12

prostaglandin E synthase 3 (cytosolic)
Identifiers
Symbol	PTGES3
Entrez	10728
HUGO	16049
OMIM	607061
RefSeq	NM_006601
UniProt	Q15185
Other data
Locus	Chr. 12 q13.13

Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism. It generates prostaglandin E (PGE) from prostaglandin H2.

The synthase generating PGE2 is a membrane-associated protein also known as mPEGS-1^[1].

Biosynthesis of eicosanoids.

references

External links

Template:Enzyme-stub

v • d • e Intramolecular oxidoreductases isomerases (EC 5.3)
5.3.1 - Aldoses/Ketoses	Triosephosphate isomerase - Phosphopentose isomerase - Mannose phosphate isomerase - Glucose isomerase
5.3.3 - C=C	Isopentenyl-diphosphate delta isomerase - Enoyl CoA isomerase
5.3.4 - S-S	Protein disulfide isomerase (PDIA3)
5.3.99 - other	Prostaglandin D2 synthase - Prostaglandin E synthase - Prostacyclin synthase - Thromboxane-A synthase

v • d • e Metabolism: lipid metabolism
Lipid production	Acetyl-CoA carboxylase - Fatty acid synthesis: Beta-ketoacyl-ACP synthase - Β-Ketoacyl ACP reductase - 3-Hydroxyacyl ACP dehydrase - Enoyl ACP reductase unsaturated (Enoyl CoA isomerase, 2,4 Dienoyl-CoA reductase) - odd chain (Propionyl-CoA carboxylase) - Fatty acid synthase - Long fatty acyl CoA synthetase
Lipid degradation	Acyl transport: Carnitine palmitoyltransferase I - Carnitine-acylcarnitine translocase - Carnitine palmitoyltransferase II Beta oxidation: Acyl CoA dehydrogenase (ACADL, ACADM, ACADS, ACADVL) - Enoyl-CoA hydratase - 3-Hydroxyacyl CoA dehydrogenase - Acetyl-CoA C-acyltransferase - Mitochondrial trifunctional protein Ketogenesis: HMG-CoA synthase - HMG-CoA lyase - Other: Malonyl-CoA decarboxylase
Phospholipids	Diacylglycerol kinase
Steroids	HMG-CoA reductase - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1
Prostanoids	Cyclooxygenase - Thromboxane-A synthase - Prostacyclin synthase - Prostaglandin E synthase - Prostaglandin D2 synthase
Leukotrienes	Arachidonate 5-lipoxygenase - 5-Lipoxygenase activating protein - Leukotriene A4 hydrolase - Leukotriene C4 synthase
Bile acids	Cholesterol 7 alpha-hydroxylase