Protamine

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protamine 1
Identifiers
Symbol	PRM1
Entrez	5619
HUGO	9447
OMIM	182880
RefSeq	NM_002761
UniProt	P04553
Other data
Locus	Chr. 16 p13.13

protamine 2
Identifiers
Symbol	PRM2
Entrez	5620
HUGO	9448
OMIM	182890
RefSeq	NM_002762
UniProt	P04554
Other data
Locus	Chr. 16 p13.13

WikiDoc Resources for Protamine
Articles
Most recent articles on Protamine Most cited articles on Protamine Review articles on Protamine Articles on Protamine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Protamine Images of Protamine Photos of Protamine Podcasts & MP3s on Protamine Videos on Protamine
Evidence Based Medicine
Cochrane Collaboration on Protamine Bandolier on Protamine TRIP on Protamine
Clinical Trials
Ongoing Trials on Protamine at Clinical Trials.gov Trial results on Protamine Clinical Trials on Protamine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Protamine NICE Guidance on Protamine NHS PRODIGY Guidance FDA on Protamine CDC on Protamine
Books
Books on Protamine
News
Protamine in the news Be alerted to news on Protamine News trends on Protamine
Commentary
Blogs on Protamine
Definitions
Definitions of Protamine
Patient Resources / Community
Patient resources on Protamine Discussion groups on Protamine Patient Handouts on Protamine Directions to Hospitals Treating Protamine Risk calculators and risk factors for Protamine
Healthcare Provider Resources
Symptoms of Protamine Causes & Risk Factors for Protamine Diagnostic studies for Protamine Treatment of Protamine
Continuing Medical Education (CME)
CME Programs on Protamine
International
Protamine en Espanol Protamine en Francais
Businness
Protamine in the Marketplace Patents on Protamine
Experimental / Informatics
List of terms related to Protamine

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Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization.

Function

When mixed with insulin, protamines slow down the onset and increase the duration of insulin action (see NPH insulin).

Protamine sulfate is an antidote for heparin.

Examples

Mice, humans, and certain fish have 2 or more different protamines, whereas the sperm of bull, boar, rat, rabbit, guinea pig, and ram have one form of protamine.

Human

The 2 human protamines are denoted PRM1 and PRM2.

External links

• MeSH Protamines
• V03AB14

v • d • e Antidotes (V03AB)
Methanol / Ethylene glycol	Ethanol - Fomepizole
Paracetamol (Acetaminophen)	Acetylcysteine - Glutathione - Methionine
Arsenic	Dimercaprol - Succimer
Cyanide	4-Dimethylaminophenol - Amyl nitrite - Hydroxocobalamin - Sodium nitrite - Sodium thiosulfate
Heparin	Protamine
Nerve agent / Organophosphate pesticide	Atropine - Biperiden - Diazepam - Oximes (Pralidoxime, Obidoxime) - see also Cholinesterase
Opioid	Diprenorphine - Nalorphine - Naloxone - Naltrexone - Nalmefene
Benzodiazepine	Flumazenil
Toxic metals (Cadmium, Mercury, Lead etc)	Edetates - Dimercaprol
Other	Ipecacuanha - Prednisolone/promethazine - Methylthioninium chloride - Potassium permanganate - Physostigmine - Copper sulfate - Potassium iodide - Digoxin Immune Fab - Prussian blue

v • d • e WikiDoc Research Resources for Protamine
Articles on Protamine	Most recent articles on Protamine • Most cited articles on Protamine • Review articles on Protamine • Articles on Protamine in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Protamine	Powerpoint slides on Protamine • Images of Protamine • Photos of Protamine • Podcasts & MP3s on Protamine • Videos on Protamine
Evidence Based Medicine Regarding Protamine	Cochrane Collaboration on Protamine • Bandolier on Protamine • TRIP on Protamine
Cost Effectiveness of Protamine	Cost Effectiveness of Protamine
Clinical Trials Involving Protamine	Ongoing Trials on Protamine at Clinical Trials.gov • Trial results on Protamine • Clinical Trials on Protamine at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Protamine	US National Guidelines Clearinghouse on Protamine • NICE Guidance on Protamine • NHS PRODIGY Guidance • FDA on Protamine • CDC on Protamine
Textbook Information on Protamine	Books and Textbook Information on Protamine
Pharmacology Resources on Protamine	Dosing of Protamine • Drug interactions with Protamine • Side effects of Protamine • Allergic reactions to Protamine • Overdose information on Protamine • Carcinogenicity information on Protamine • Protamine in pregnancy • Pharmacokinetics of Protamine •
Genetics, Pharmacogenomics, and Proteinomics of Protamine	Genetics of Protamine • Pharmacogenomics of Protamine • Proteomics of Protamine
Newstories on Protamine	Protamine in the news • Be alerted to news on Protamine • News trends on Protamine
Commentary on Protamine	Blogs on Protamine
Patient Resources on Protamine	Patient resources on Protamine • Discussion groups on Protamine • Patient Handouts on Protamine • Directions to Hospitals Treating Protamine • Risk calculators and risk factors for Protamine
Healthcare Provider Resources on Protamine	Symptoms of Protamine • Causes & Risk Factors for Protamine • Diagnostic studies for Protamine • Treatment of Protamine
Continuing Medical Education (CME) Programs on Protamine	CME Programs on Protamine
International Resources on Protamine	Protamine en Espanol • Protamine en Francais
Business Resources on Protamine	Protamine in the Marketplace • Patents on Protamine
Informatics Resources on Protamine	List of terms related to Protamine

it:Protammina

ja:プロタミン

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .