Prothrombinase

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WikiDoc Resources for Prothrombinase
Articles
Most recent articles on Prothrombinase Most cited articles on Prothrombinase Review articles on Prothrombinase Articles on Prothrombinase in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Prothrombinase Images of Prothrombinase Photos of Prothrombinase Podcasts & MP3s on Prothrombinase Videos on Prothrombinase
Evidence Based Medicine
Cochrane Collaboration on Prothrombinase Bandolier on Prothrombinase TRIP on Prothrombinase
Clinical Trials
Ongoing Trials on Prothrombinase at Clinical Trials.gov Trial results on Prothrombinase Clinical Trials on Prothrombinase at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Prothrombinase NICE Guidance on Prothrombinase NHS PRODIGY Guidance FDA on Prothrombinase CDC on Prothrombinase
Books
Books on Prothrombinase
News
Prothrombinase in the news Be alerted to news on Prothrombinase News trends on Prothrombinase
Commentary
Blogs on Prothrombinase
Definitions
Definitions of Prothrombinase
Patient Resources / Community
Patient resources on Prothrombinase Discussion groups on Prothrombinase Patient Handouts on Prothrombinase Directions to Hospitals Treating Prothrombinase Risk calculators and risk factors for Prothrombinase
Healthcare Provider Resources
Symptoms of Prothrombinase Causes & Risk Factors for Prothrombinase Diagnostic studies for Prothrombinase Treatment of Prothrombinase
Continuing Medical Education (CME)
CME Programs on Prothrombinase
International
Prothrombinase en Espanol Prothrombinase en Francais
Businness
Prothrombinase in the Marketplace Patents on Prothrombinase
Experimental / Informatics
List of terms related to Prothrombinase

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Prothrombinase is the protein complex which consist of negatively charged phospholipid (phosphatidylserine), prothrombin, Va and Xa.

The prothrombinase complex converts prothrombin, an inactive protease, into thrombin which has proteolytic activity.

Assembly of the prothrombinase complex occurs on activated platelets. In normal conditions platelets do not expose negatively charged phospholipids on the surface. However binding to collagen sets a sequence of biochemical reactions in motion that activate the membrane protein scramblase. Scramblase transports negatively charged phospholipids from the inner leaflet of the membrane to the outer leaflet. The presence of negatively charged phospholipids allows the binding and the formation of the prothrombinase complex.

See also

hemostasis

v • d • e Blood
General	Plasma – Hematopoietic stem cells
Lymphoid – WBC	T cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell B cells: Plasma, Memory Natural killer cells (Lymphokine-activated killer cell) Null cell
Myeloid – WBC	Monocytes/Macrophages (Histiocytes, Kupffer cells, Langhans giant cells, Microglia, Osteoclasts, Epithelioid cells) Granulocytes (Neutrophil, Eosinophil, Basophil) – Mast cell precursors Dendritic cells (Langerhans cells, Follicular dendritic cells) Megakaryoblast – Megakaryocyte – Platelets
Myeloid – RBC	Reticulocyte – Normoblast

v • d • e WikiDoc Research Resources for Prothrombinase (Click show to right to view)
Articles on Prothrombinase	Most recent articles on Prothrombinase • Most cited articles on Prothrombinase • Review articles on Prothrombinase • Articles on Prothrombinase in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Prothrombinase	Powerpoint slides on Prothrombinase • Images of Prothrombinase • Photos of Prothrombinase • Podcasts & MP3s on Prothrombinase • Videos on Prothrombinase
Evidence Based Medicine Regarding Prothrombinase	Cochrane Collaboration on Prothrombinase • Bandolier on Prothrombinase • TRIP on Prothrombinase
Cost Effectiveness of Prothrombinase	Cost Effectiveness of Prothrombinase
Clinical Trials Involving Prothrombinase	Ongoing Trials on Prothrombinase at Clinical Trials.gov • Trial results on Prothrombinase • Clinical Trials on Prothrombinase at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Prothrombinase	US National Guidelines Clearinghouse on Prothrombinase • NICE Guidance on Prothrombinase • NHS PRODIGY Guidance • FDA on Prothrombinase • CDC on Prothrombinase
Textbook Information on Prothrombinase	Books and Textbook Information on Prothrombinase
Pharmacology Resources on Prothrombinase	Dosing of Prothrombinase • Drug interactions with Prothrombinase • Side effects of Prothrombinase • Allergic reactions to Prothrombinase • Overdose information on Prothrombinase • Carcinogenicity information on Prothrombinase • Prothrombinase in pregnancy • Pharmacokinetics of Prothrombinase •
Genetics, Pharmacogenomics, and Proteinomics of Prothrombinase	Genetics of Prothrombinase • Pharmacogenomics of Prothrombinase • Proteomics of Prothrombinase
Newstories on Prothrombinase	Prothrombinase in the news • Be alerted to news on Prothrombinase • News trends on Prothrombinase
Commentary on Prothrombinase	Blogs on Prothrombinase
Patient Resources on Prothrombinase	Patient resources on Prothrombinase • Discussion groups on Prothrombinase • Patient Handouts on Prothrombinase • Directions to Hospitals Treating Prothrombinase • Risk calculators and risk factors for Prothrombinase
Healthcare Provider Resources on Prothrombinase	Symptoms of Prothrombinase • Causes & Risk Factors for Prothrombinase • Diagnostic studies for Prothrombinase • Treatment of Prothrombinase
Continuing Medical Education (CME) Programs on Prothrombinase	CME Programs on Prothrombinase
International Resources on Prothrombinase	Prothrombinase en Espanol • Prothrombinase en Francais
Business Resources on Prothrombinase	Prothrombinase in the Marketplace • Patents on Prothrombinase
Informatics Resources on Prothrombinase	List of terms related to Prothrombinase

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .