Pseudo-Cushing's syndrome

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Pseudo-Cushing's syndrome Classification and external resources
ICD-10	E24.3
eMedicine	med/1936

WikiDoc Resources for Pseudo-Cushing's syndrome
Articles
Most recent articles on Pseudo-Cushing's syndrome Most cited articles on Pseudo-Cushing's syndrome Review articles on Pseudo-Cushing's syndrome Articles on Pseudo-Cushing's syndrome in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Pseudo-Cushing's syndrome Images of Pseudo-Cushing's syndrome Photos of Pseudo-Cushing's syndrome Podcasts & MP3s on Pseudo-Cushing's syndrome Videos on Pseudo-Cushing's syndrome
Evidence Based Medicine
Cochrane Collaboration on Pseudo-Cushing's syndrome Bandolier on Pseudo-Cushing's syndrome TRIP on Pseudo-Cushing's syndrome
Clinical Trials
Ongoing Trials on Pseudo-Cushing's syndrome at Clinical Trials.gov Trial results on Pseudo-Cushing's syndrome Clinical Trials on Pseudo-Cushing's syndrome at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Pseudo-Cushing's syndrome NICE Guidance on Pseudo-Cushing's syndrome NHS PRODIGY Guidance FDA on Pseudo-Cushing's syndrome CDC on Pseudo-Cushing's syndrome
Books
Books on Pseudo-Cushing's syndrome
News
Pseudo-Cushing's syndrome in the news Be alerted to news on Pseudo-Cushing's syndrome News trends on Pseudo-Cushing's syndrome
Commentary
Blogs on Pseudo-Cushing's syndrome
Definitions
Definitions of Pseudo-Cushing's syndrome
Patient Resources / Community
Patient resources on Pseudo-Cushing's syndrome Discussion groups on Pseudo-Cushing's syndrome Patient Handouts on Pseudo-Cushing's syndrome Directions to Hospitals Treating Pseudo-Cushing's syndrome Risk calculators and risk factors for Pseudo-Cushing's syndrome
Healthcare Provider Resources
Symptoms of Pseudo-Cushing's syndrome Causes & Risk Factors for Pseudo-Cushing's syndrome Diagnostic studies for Pseudo-Cushing's syndrome Treatment of Pseudo-Cushing's syndrome
Continuing Medical Education (CME)
CME Programs on Pseudo-Cushing's syndrome
International
Pseudo-Cushing's syndrome en Espanol Pseudo-Cushing's syndrome en Francais
Businness
Pseudo-Cushing's syndrome in the Marketplace Patents on Pseudo-Cushing's syndrome
Experimental / Informatics
List of terms related to Pseudo-Cushing's syndrome

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Pseudo-Cushing's syndrome is a medical condition in which patients display the signs, symptoms, and abnormal hormone levels seen in Cushing's syndrome. Pseudo-Cushing's syndrome, however, is not caused by a problem with the hypothalamic-pituitary-adrenal axis as Cushing's is. It is an idiopathic condition.

Investigations

• Levels of cortisol and ACTH are both high
• 24-hour urinary cortisol levels are high
• Dexamethasone suppression test fails to suppress serum cortisol
• Loss of diurnal variation in cortisol levels- Loss of Diurnal Variation is seen only in true Cushing's Syndrome or Disease.
• High mean corpuscular volume and gamma-glutamyl transferase may be clues to alcoholism
• Polycystic Ovarian Syndrome should be ruled out, since PCOS has similar symptoms.

Differential diagnosis

• Differentiation from Cushing's is extremely difficult
• Causes of Cushing's should be excluded with imaging of the lungs, adrenal glands, and pituitary gland - but these often appear normal in Cushing's anyway
• In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within 5 days, excluding Cushing's^[1]

Prognosis

• Blood results and symptoms normalise rapidly on cessation of drinking or remission of depression

References

v • d • e Endocrine pathology: endocrine diseases (E00-35, 240-259)
Thyroid	Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome
Pancreas	Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome)
Parathyroid	Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)
Pituitary	Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease/Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy - Empty sella syndrome
Adrenal	Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism
Gonads	ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - testicular dysfunction (5-alpha-reductase deficiency) - testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - general (Hypogonadism, Delayed puberty, Precocious puberty)
Other	Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome

v • d • e WikiDoc Research Resources for Pseudo-Cushing's syndrome
Articles on Pseudo-Cushing's syndrome	Most recent articles on Pseudo-Cushing's syndrome • Most cited articles on Pseudo-Cushing's syndrome • Review articles on Pseudo-Cushing's syndrome • Articles on Pseudo-Cushing's syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Pseudo-Cushing's syndrome	Powerpoint slides on Pseudo-Cushing's syndrome • Images of Pseudo-Cushing's syndrome • Photos of Pseudo-Cushing's syndrome • Podcasts & MP3s on Pseudo-Cushing's syndrome • Videos on Pseudo-Cushing's syndrome
Evidence Based Medicine Regarding Pseudo-Cushing's syndrome	Cochrane Collaboration on Pseudo-Cushing's syndrome • Bandolier on Pseudo-Cushing's syndrome • TRIP on Pseudo-Cushing's syndrome
Cost Effectiveness of Pseudo-Cushing's syndrome	Cost Effectiveness of Pseudo-Cushing's syndrome
Clinical Trials Involving Pseudo-Cushing's syndrome	Ongoing Trials on Pseudo-Cushing's syndrome at Clinical Trials.gov • Trial results on Pseudo-Cushing's syndrome • Clinical Trials on Pseudo-Cushing's syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pseudo-Cushing's syndrome	US National Guidelines Clearinghouse on Pseudo-Cushing's syndrome • NICE Guidance on Pseudo-Cushing's syndrome • NHS PRODIGY Guidance • FDA on Pseudo-Cushing's syndrome • CDC on Pseudo-Cushing's syndrome
Textbook Information on Pseudo-Cushing's syndrome	Books and Textbook Information on Pseudo-Cushing's syndrome
Pharmacology Resources on Pseudo-Cushing's syndrome	Dosing of Pseudo-Cushing's syndrome • Drug interactions with Pseudo-Cushing's syndrome • Side effects of Pseudo-Cushing's syndrome • Allergic reactions to Pseudo-Cushing's syndrome • Overdose information on Pseudo-Cushing's syndrome • Carcinogenicity information on Pseudo-Cushing's syndrome • Pseudo-Cushing's syndrome in pregnancy • Pharmacokinetics of Pseudo-Cushing's syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Pseudo-Cushing's syndrome	Genetics of Pseudo-Cushing's syndrome • Pharmacogenomics of Pseudo-Cushing's syndrome • Proteomics of Pseudo-Cushing's syndrome
Newstories on Pseudo-Cushing's syndrome	Pseudo-Cushing's syndrome in the news • Be alerted to news on Pseudo-Cushing's syndrome • News trends on Pseudo-Cushing's syndrome
Commentary on Pseudo-Cushing's syndrome	Blogs on Pseudo-Cushing's syndrome
Patient Resources on Pseudo-Cushing's syndrome	Patient resources on Pseudo-Cushing's syndrome • Discussion groups on Pseudo-Cushing's syndrome • Patient Handouts on Pseudo-Cushing's syndrome • Directions to Hospitals Treating Pseudo-Cushing's syndrome • Risk calculators and risk factors for Pseudo-Cushing's syndrome
Healthcare Provider Resources on Pseudo-Cushing's syndrome	Symptoms of Pseudo-Cushing's syndrome • Causes & Risk Factors for Pseudo-Cushing's syndrome • Diagnostic studies for Pseudo-Cushing's syndrome • Treatment of Pseudo-Cushing's syndrome
Continuing Medical Education (CME) Programs on Pseudo-Cushing's syndrome	CME Programs on Pseudo-Cushing's syndrome
International Resources on Pseudo-Cushing's syndrome	Pseudo-Cushing's syndrome en Espanol • Pseudo-Cushing's syndrome en Francais
Business Resources on Pseudo-Cushing's syndrome	Pseudo-Cushing's syndrome in the Marketplace • Patents on Pseudo-Cushing's syndrome
Informatics Resources on Pseudo-Cushing's syndrome	List of terms related to Pseudo-Cushing's syndrome

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .