Septic arthritis
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| Septic arthritis Classification and external resources | |
| ICD-10 | M00-M03 |
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| ICD-9 | 711.0 |
| eMedicine | med/3394 |
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Septic arthritis is the invasion of the joint space by an infectious agent which produces arthritis. The usual etiology is bacterial, but viral, mycobacterial, and fungal arthritis occur occasionally. Bacteria are either carried by the bloodstream from an infectious focus elsewhere, introduced by a skin lesion that penetrates the joint, or by extension from adjacent tissue (e.g. bone or bursae).
Etiology
For bacterial infection, Pseudomonas aeruginosa has been found to infect joints, for example in children who have sustained a puncture wound. This bacteria also causes endocarditis.[1]
In newborns, the most common pathogen is Group B Streptococci. In children older than 2 or 3, about 50% are due to Staphylococcus aureus. Haemophilus influenzae type B used to be a major cause before the use of the vaccine. In sexually active individuals, a major cause is Neisseria gonorrhoeae.
Indications
Septic arthritis should be suspected when one joint (monoarthritis) is affected and the patient is febrile. In seeding arthritis, several joints can be affected simultaneously; this is especially the case when the infection is caused by staphylococcus or gonococcus bacteria.
Diagnosis is by aspiration (giving a turbid, non-viscous fluid), Gram stain and culture of fluid from the joint, as well as tell-tale signs in laboratory testing (such as a highly elevated neutrophils (approx. 90%), ESR or CRP).
Treatment
Therapy is usually with intravenous antibiotics, analgesia and washout/aspiration of the joint to dryness.
Radiologic Findings
Traditionally, the diagnosis of septic arthritis was based on clinical assessment and prompt arthrocentesis. However, the clinical picture may be obscured by multiple confounding factors and a paucity of specific findings especially for the deep joints, ie. the hip or shoulder. Imaging can be used to confirm the diagnosis of septic arthritis and more importantly, imaging findings suggestive of septic arthritis can direct the clinician to a diagnosis that may not have been considered.
Plain film findings of septic arthritis include: joint effusion, soft tissue swelling, periarticular osteoporosis, loss of joint space, marginal and central erosions and bone ankylosis. CT is more sensitive than plain films for the detection of early bone destruction and effusion.
The role of MRI in the diagnosis of septic arthritis has been increasing in recent years in an effort to detect this entity earlier. Findings are usually evident within 24 hours following the onset of infection and include: synovial enhancement, perisynovial edema and joint effusion. Signal abnormalities in the bone marrow can indicate a concomitant osteomyelitis. The sensitivity and specificity of MRI for the detection of septic arthritis has been reported to be 100% and 77% respectively.
See also
References
Additional Resources
- Septic arthritis by William Brinkman, M.D., University of Washington Department of Radiology
- Karchevsky M, Schweitzer ME, Morrison WB, Parellada JA. MRI findings of septic arthritis and associated osteomyelitis in adults. AJR 2004; 182:119-122.
- Resnick D. Bone and joint imaging. Philadelphia, PA: WB Saunders Co; 1989; 744-749
- Stoller DW, Tirman P, Bredella MA. Diagnostic imaging orthopaedics. Salt Lake City, UT: Amirsys; 2004; 4-99.
- Edwards MS. "Osteomyelitis and Septic Arthritis"
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
