Pyridoxine deficiency

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Overview

Vitamin B6 deficiency Classification and external resources
ICD-10	E53.1
ICD-9	266.1
DiseasesDB	13923
eMedicine	med/1977
MeSH	D026681

WikiDoc Resources for Pyridoxine deficiency
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Evidence Based Medicine
Cochrane Collaboration on Pyridoxine deficiency Bandolier on Pyridoxine deficiency TRIP on Pyridoxine deficiency
Clinical Trials
Ongoing Trials on Pyridoxine deficiency at Clinical Trials.gov Trial results on Pyridoxine deficiency Clinical Trials on Pyridoxine deficiency at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Pyridoxine deficiency NICE Guidance on Pyridoxine deficiency NHS PRODIGY Guidance FDA on Pyridoxine deficiency CDC on Pyridoxine deficiency
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News
Pyridoxine deficiency in the news Be alerted to news on Pyridoxine deficiency News trends on Pyridoxine deficiency
Commentary
Blogs on Pyridoxine deficiency
Definitions
Definitions of Pyridoxine deficiency
Patient Resources / Community
Patient resources on Pyridoxine deficiency Discussion groups on Pyridoxine deficiency Patient Handouts on Pyridoxine deficiency Directions to Hospitals Treating Pyridoxine deficiency Risk calculators and risk factors for Pyridoxine deficiency
Healthcare Provider Resources
Symptoms of Pyridoxine deficiency Causes & Risk Factors for Pyridoxine deficiency Diagnostic studies for Pyridoxine deficiency Treatment of Pyridoxine deficiency
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International
Pyridoxine deficiency en Espanol Pyridoxine deficiency en Francais
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Experimental / Informatics
List of terms related to Pyridoxine deficiency

The classic clinical syndrome for Pyridoxine deficiency (or B6 deficiency) is a seborrheic dermatitis-like eruption, atrophic glossitis with ulceration, angular cheilitis, conjunctivitis, intertrigo, and neurologic symptoms of somnolence, confusion, and neuropathy.^[1]

Vitamin B6 is a co-factor for glutamic acid decarboxylase, an enzyme that converts Glutamate to GABA. Therefore, the concurrent increase in the excitatory neurotransmitter, Glutamate, and decrease in inhibitory neurotransmitter, GABA, resultant from B6 deficiency, may manifest itself in the form of seizures.

Causes

• Supporters of a debated medical condition known as Pyroluria believe it may be one potential cause of vitamin B6 deficiency.
• Another cause of vitamin B6 deficiency is the use of the tuberculostatic medication isoniazid, and for this reason, it is recommended to supplement with vitamin B6 when using this drug.
• Grumpiness and irritability are also often symptomatic of a deficiency according to "Body, Mind, and the B Vitamins" by Ruth Adams and Frank Murray.
• A meta-analysis of three databases (MEDLINE, EMBASE, and Cochrane Library), including only double-blind, randomized controlled trials, found that vitamin B6 has a significant effect compared to placebos in treating morning sickness, similar to that of ginger.^[1]

Diagnostic Testing for B6 Deficiency

A positive diagnosis test for pyridoxine deficiency can be assertained by measuring erythrocyte levels of aspartate aminotransferase and transketolase in serum.

Differential Diagnosis

• Advanced Age
• Alcoholism
• Catabolic state
• Celiac Disease
• Chronic Renal Failure
• Drugs
• Extrahepatic biliary obstruction
• Hemodialysis
• Hepatocellular Carcinoma
• Hepatitis
• Hospitalization
• Hyperoxaluria
• Kidney transplant
• Peritoneal dialysis
• Severe malnutrition ^[1]

References

v • d • e WikiDoc Research Resources for Pyridoxine deficiency (Click show to right to view)
Articles on Pyridoxine deficiency	Most recent articles on Pyridoxine deficiency • Most cited articles on Pyridoxine deficiency • Review articles on Pyridoxine deficiency • Articles on Pyridoxine deficiency in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Pyridoxine deficiency	Powerpoint slides on Pyridoxine deficiency • Images of Pyridoxine deficiency • Photos of Pyridoxine deficiency • Podcasts & MP3s on Pyridoxine deficiency • Videos on Pyridoxine deficiency
Evidence Based Medicine Regarding Pyridoxine deficiency	Cochrane Collaboration on Pyridoxine deficiency • Bandolier on Pyridoxine deficiency • TRIP on Pyridoxine deficiency
Cost Effectiveness of Pyridoxine deficiency	Cost Effectiveness of Pyridoxine deficiency
Clinical Trials Involving Pyridoxine deficiency	Ongoing Trials on Pyridoxine deficiency at Clinical Trials.gov • Trial results on Pyridoxine deficiency • Clinical Trials on Pyridoxine deficiency at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pyridoxine deficiency	US National Guidelines Clearinghouse on Pyridoxine deficiency • NICE Guidance on Pyridoxine deficiency • NHS PRODIGY Guidance • FDA on Pyridoxine deficiency • CDC on Pyridoxine deficiency
Textbook Information on Pyridoxine deficiency	Books and Textbook Information on Pyridoxine deficiency
Pharmacology Resources on Pyridoxine deficiency	Dosing of Pyridoxine deficiency • Drug interactions with Pyridoxine deficiency • Side effects of Pyridoxine deficiency • Allergic reactions to Pyridoxine deficiency • Overdose information on Pyridoxine deficiency • Carcinogenicity information on Pyridoxine deficiency • Pyridoxine deficiency in pregnancy • Pharmacokinetics of Pyridoxine deficiency •
Genetics, Pharmacogenomics, and Proteinomics of Pyridoxine deficiency	Genetics of Pyridoxine deficiency • Pharmacogenomics of Pyridoxine deficiency • Proteomics of Pyridoxine deficiency
Newstories on Pyridoxine deficiency	Pyridoxine deficiency in the news • Be alerted to news on Pyridoxine deficiency • News trends on Pyridoxine deficiency
Commentary on Pyridoxine deficiency	Blogs on Pyridoxine deficiency
Patient Resources on Pyridoxine deficiency	Patient resources on Pyridoxine deficiency • Discussion groups on Pyridoxine deficiency • Patient Handouts on Pyridoxine deficiency • Directions to Hospitals Treating Pyridoxine deficiency • Risk calculators and risk factors for Pyridoxine deficiency
Healthcare Provider Resources on Pyridoxine deficiency	Symptoms of Pyridoxine deficiency • Causes & Risk Factors for Pyridoxine deficiency • Diagnostic studies for Pyridoxine deficiency • Treatment of Pyridoxine deficiency
Continuing Medical Education (CME) Programs on Pyridoxine deficiency	CME Programs on Pyridoxine deficiency
International Resources on Pyridoxine deficiency	Pyridoxine deficiency en Espanol • Pyridoxine deficiency en Francais
Business Resources on Pyridoxine deficiency	Pyridoxine deficiency in the Marketplace • Patents on Pyridoxine deficiency
Informatics Resources on Pyridoxine deficiency	List of terms related to Pyridoxine deficiency

v • d • e Nutritional pathology (E40-68, 260-269)
Malnutrition	Kwashiorkor - Marasmus - Catabolysis
Avitaminosis	B vitamins: B1: Beriberi/Wernicke's encephalopathy, B2: Ariboflavinosis, B3: Pellagra, B6: Pyridoxine deficiency, B7: Biotin deficiency, B9: Folate deficiency, B12: Vitamin B12 deficiency other vitamins: A: Vitamin A deficiency/Bitot's spots, C: Scurvy, D: Rickets/Osteomalacia
Mineral deficiency	Zinc deficiency - Iron deficiency - Magnesium deficiency - Chromium deficiency
Hyperalimentation	Obesity - Vitamin poisoning (Hypervitaminosis A, Hypervitaminosis D, Hypervitaminosis E)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .