RANK

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tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Identifiers
Symbol	TNFRSF11A
Entrez	8792
HUGO	11908
OMIM	603499
RefSeq	NM_003839
UniProt	Q9Y6Q6
Other data
Locus	Chr. 18 q22.1

RANK (Receptor Activator of Nuclear Factor κ B), also known as TRANCE Receptor, is a type I membrane protein which is expressed on the surface of osteoclasts and is involved in the activation of osteoclasts upon ligand binding. It is also expressed on dendritic cells and facilitates immune signaling. RANK ligand is found on the surface of stromal cells, osteoblasts, and T cells.

See also

• RANKL
• Osteoimmunology

External links

• MeSH RANK+Protein

• Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795-823. doi:10.1146/annurev.immunol.20.100301.064753. PMID 11861618.

v • d • e Cytokine receptors: tumor necrosis factor receptor superfamily
CD27 - CD30 - CD40 - CD120 - CD134 - CD137 - Fas receptor (CD95) - Lymphotoxin beta receptor - Osteoprotegerin - RANK - TNFRSF10A

de:RANK

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .