RANKL

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tumor necrosis factor (ligand) superfamily, member 11
Identifiers
Symbol	TNFSF11
Entrez	8600
HUGO	11926
OMIM	602642
RefSeq	NM_003701
UniProt	O14788
Other data
Locus	Chr. 13 q14

RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor) is a molecule important in bone metabolism. This natural and necessary surface-bound molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and osteomyelitis. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation.

See also

• RANK
• Osteoprotegerin
• Osteoimmunology

Reference

• Whyte M (2006). "The long and the short of bone therapy". N Engl J Med 354 (8): 860-3. PMID 16495400. link

External links

• http://www.networksandpathways.org/pathway?name=RANKL&description=RANKL
• MeSH RANKL+Protein

v • d • e Cytokines: Tumor necrosis factors
Tumor necrosis factor-alpha
Tumor necrosis factor (ligand) superfamily	4-1BB ligand - B-cell activating factor - FAS ligand - Lymphotoxin - OX40L - RANKL - TRAIL
Cluster of differentiation	CD70 - CD153 - CD154

de:RANKL

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .