Seminoma
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| Seminoma Classification and external resources | |
| ICD-10 | C62. |
|---|---|
| ICD-9 | 186 |
| ICD-O: | 9061 |
| OMIM | 273300 |
| DiseasesDB | 12966 |
| eMedicine | med/2250 |
| MeSH | D018239 |
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Overview
Seminoma is one type of testicular cancer[1] that is believed to originate from the germinal epithelium of the seminiferous tubules.
Presentation
They produce bulky masses that can be up to ten times the size of a normal testis.
Diagnosis
POU2AF1 and PROM1 have been proposed as possible markers.[2]
Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear sytoplasm, distinct cell membranes, and septated arcitecture.
Treatment
In recent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy. The management of childhood seminoma is similar to that of adult seminoma. Orchiectomy is required in almost all cases.
References
- ↑ s_07/12728548 at Dorland's Medical Dictionary
- ↑ Gashaw I, Dushaj O, Behr R, et al (2007). "Novel germ cell markers characterize testicular seminoma and fetal testis". Mol. Hum. Reprod. 13 (10): 721–7. doi:10.1093/molehr/gam059. PMID 17785371.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
