Sheehan's syndrome

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Sheehan syndrome Classification and external resources
ICD-10	E23.0
ICD-9	253.2
DiseasesDB	11998
MedlinePlus	001175
eMedicine	med/1914
MeSH	D007018

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Sheehan syndrome, also known as postpartum hypopituitarism or postpartum pituitary necrosis, is hypopituitarism (decreased functioning of the pituitary gland), caused by necrosis due to blood loss and hypovolemic shock during and after childbirth.

Causes

It is a rare complication of pregnancy, usually occurring after excessive blood loss; the presence of disseminated intravascular coagulation (e. in amniotic fluid embolism or HELLP syndrome) also appears to be a factor in its development.

Pathophysiology

Hypertrophy and hyperplasia of lactotrophs during pregnancy results in the enlargement of the anterior pituitary, without a corresponding increase in blood supply.

Secondly, the anterior pituitary is supplied by a low pressure portal venous system.

These vulnerabilities, when affected by major hemorrhage or hypotension during the peripartum period, can result in ischaemia of the affected pituitary regions leading to necrosis.

The posterior pituitary is usually not affected due to its direct arterial supply.

Eponym

It is named for Harold Sheehan.^[1][1]

References

External links

• 617611278 at GPnotebook
• Pathology at vcu.edu

v • d • e Endocrine pathology: endocrine diseases (E00-35, 240-259)
Thyroid	Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome
Pancreas	Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome)
Parathyroid	Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)
Pituitary	Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease/Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy - Empty sella syndrome
Adrenal	Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism
Gonads	ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - testicular dysfunction (5-alpha-reductase deficiency) - testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - general (Hypogonadism, Delayed puberty, Precocious puberty)
Other	Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome

v • d • e WikiDoc Research Resources for Sheehan's syndrome
Articles on Sheehan's syndrome	Most recent articles on Sheehan's syndrome • Most cited articles on Sheehan's syndrome • Review articles on Sheehan's syndrome • Articles on Sheehan's syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Sheehan's syndrome	Powerpoint slides on Sheehan's syndrome • Images of Sheehan's syndrome • Photos of Sheehan's syndrome • Podcasts & MP3s on Sheehan's syndrome • Videos on Sheehan's syndrome
Evidence Based Medicine Regarding Sheehan's syndrome	Cochrane Collaboration on Sheehan's syndrome • Bandolier on Sheehan's syndrome • TRIP on Sheehan's syndrome
Cost Effectiveness of Sheehan's syndrome	Cost Effectiveness of Sheehan's syndrome
Clinical Trials Involving Sheehan's syndrome	Ongoing Trials on Sheehan's syndrome at Clinical Trials.gov • Trial results on Sheehan's syndrome • Clinical Trials on Sheehan's syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Sheehan's syndrome	US National Guidelines Clearinghouse on Sheehan's syndrome • NICE Guidance on Sheehan's syndrome • NHS PRODIGY Guidance • FDA on Sheehan's syndrome • CDC on Sheehan's syndrome
Textbook Information on Sheehan's syndrome	Books and Textbook Information on Sheehan's syndrome
Pharmacology Resources on Sheehan's syndrome	Dosing of Sheehan's syndrome • Drug interactions with Sheehan's syndrome • Side effects of Sheehan's syndrome • Allergic reactions to Sheehan's syndrome • Overdose information on Sheehan's syndrome • Carcinogenicity information on Sheehan's syndrome • Sheehan's syndrome in pregnancy • Pharmacokinetics of Sheehan's syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Sheehan's syndrome	Genetics of Sheehan's syndrome • Pharmacogenomics of Sheehan's syndrome • Proteomics of Sheehan's syndrome
Newstories on Sheehan's syndrome	Sheehan's syndrome in the news • Be alerted to news on Sheehan's syndrome • News trends on Sheehan's syndrome
Commentary on Sheehan's syndrome	Blogs on Sheehan's syndrome
Patient Resources on Sheehan's syndrome	Patient resources on Sheehan's syndrome • Discussion groups on Sheehan's syndrome • Patient Handouts on Sheehan's syndrome • Directions to Hospitals Treating Sheehan's syndrome • Risk calculators and risk factors for Sheehan's syndrome
Healthcare Provider Resources on Sheehan's syndrome	Symptoms of Sheehan's syndrome • Causes & Risk Factors for Sheehan's syndrome • Diagnostic studies for Sheehan's syndrome • Treatment of Sheehan's syndrome
Continuing Medical Education (CME) Programs on Sheehan's syndrome	CME Programs on Sheehan's syndrome
International Resources on Sheehan's syndrome	Sheehan's syndrome en Espanol • Sheehan's syndrome en Francais
Business Resources on Sheehan's syndrome	Sheehan's syndrome in the Marketplace • Patents on Sheehan's syndrome
Informatics Resources on Sheehan's syndrome	List of terms related to Sheehan's syndrome

de:Sheehan-Syndromit:Sindrome di Sheehan

ja:シーハン症候群

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .