Sinusitis

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Sinusitis Classification and external resources
ICD-10	J01., J32.
ICD-9	461, 473
DiseasesDB	12136
eMedicine	emerg/536
MeSH	D012852

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Sinusitis is an inflammation of the paranasal sinuses, which may or may not be as a result of infection, from bacterial, fungal, viral, allergic or autoimmune issues. Newer classifications of sinusitis refer to it as rhinosinusitis, taking into account the thought that inflammation of the sinuses cannot occur without some inflammation of the nose as well (rhinitis).

Classification

By location

There are several paired paranasal sinuses, including the frontal, ethmoid, maxillary and sphenoid sinuses. The ethmoid sinuses can also be further broken down into anterior and posterior, the division of which is defined as the basal lamella of the middle turbinate. In addition to the acuity of disease, discussed below, sinusitis can be classified by the sinus cavity which it affects:

• Maxillary sinusitis - can cause pain or pressure in the maxillary (cheek) area (e.g., toothache, headache) (J01.0/J32.0)

• Frontal sinusitis - can cause pain or pressure in the frontal sinus cavity (located behind/above eyes), headache (J01.1/J32.1)

• Ethmoid sinusitis - can cause pain or pressure pain between and/or behind eyes, headache (J01.2/J32.2)

• Sphenoid sinusitis - can cause pain or pressure behind the eyes, but often refers to the vertex of the head(J01.3/J32.3)

Recent theories of sinusitis indicate that it often occurs as part of a spectrum of diseases that affect the respiratory tract (i.e. - the "one airway" theory) and is often linked to asthma. All forms of sinusitis may either result in, or be a part of, a generalized inflammation of the airway so other airway symptoms such as cough may be associated with it.

By duration

Sinusitis can be acute (going on less than four weeks), subacute (4-12 weeks) or chronic (going on for 12 weeks or more).

All three types of sinusitis have similar symptoms, and are thus often difficult to distinguish.

Acute sinusitis

Acute sinusitis is usually precipitated by an earlier upper respiratory tract infection, generally of viral origin. Virally damaged surface tissues are then colonized by bacteria, most commonly Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Staphylococcus aureus. Other bacterial pathogens include other streptococci species, anaerobic bacteria and, less commonly, gram negative bacteria. Another possible cause of sinusitis can be dental problems that affect the maxillary sinus. Acute episodes of sinusitis can also result from fungal invasion. These infections are most often seen in patients with diabetes or other immune deficiencies (such as AIDS or transplant patients on anti-rejection medications) and can be life threatening. In type I diabetes, ketoacidosis causes sinusitis by Mucormycosis.

Chronic sinusitis

Chronic sinusitis is a complicated spectrum of diseases that share chronic inflammation of the sinuses in common. The causes are multifactorial and may include allergy, environmental factors such as dust or pollution, bacterial infection, and/or fungus (either allergic, infective or reactive). Non allergic factors such as Vasomotor rhinitis can also cause chronic sinus problems.

Symptoms include: Nasal congestion; facial pain; headache; fever; general malaise; thick green or yellow discharge; feeling of facial 'fullness' worsening on bending over; aching teeth.

Very rarely, chronic sinusitis can lead to Anosmia, the inability to smell or detect odors.

In a small number of cases, chronic maxillary sinusitis can also be brought on by the spreading of bacteria from a dental infection.

Attempts have been made to provide a more consistent nomenclature for subtypes of chronic sinusitis. A task force for the American Academy of Otolaryngology - Head and Neck Surgery / Foundation along with the Sinus and Allergy Health Partnership broke Chronic Sinusitis into two main divisions, Chronic Sinusitis without polyps and Chronic Sinusitis with polyps (also often referred to as Chronic Hyperplastic Sinusitis). Recent studies which have sought to further determine and characterize a common pathologic progression of disease have resulted in an expansion of proposed subtypes. Many patients have demonstrated the presence of eosinophils in the mucous lining of the nose and paranasal sinuses. As such the name Eosinophilic Mucin RhinoSinusitis (EMRS) has come into being. Cases of EMRS may be related to an allergic response, but allergy is often not documentable, resulting in further subcategorization of allergic and non-allergic EMRS.

A more recent, and still debated, development in chronic sinusitis is the role that fungus may play. Fungus can be found in the nasal cavities and sinuses of most patients with sinusitis, but can also be found in healthy people as well. It remains unclear if fungus is a definite factor in the development of chronic sinusitis and if it is, what the difference may be between those who develop the disease and those who do not.

Role of biofilms

Biofilms are complex aggregates of extracellular matrix and inter-dependant microorganisms from multiple species, many of which may be difficult or impossible to isolate using standard clinical laboratory techniques. Bacteria found in biofilms may show increased antibiotic resistance when compared to free-living bacteria of the same species. It has been hypothesized that biofilm-type infections may account for many cases of antibiotic-refractory chronic sinusitis.^[1] A recent study found that biofilms were present on the mucosa of 3/4 of patients undergoing surgery for chronic sinusitis.^[2]

Sinus headache vs migraine

Headache is rarely a symptom of sinusitis and a "sinus headache" is often a misdiagnosis of a migraine. Acute sinusitis can cause pressure within the sinus cavities of the head, but this typically has associated pain to palpation of the sinus area and purulent greenish discharge from the nose. The use of the term sinus headache therefore is often misleading and results in underdiagnosis of migraine. Recent studies indicate that up to 90% of "sinus headaches" are migraine ^[3][4] This confusion occurs in part because migraine involves activation of the trigeminal nerves which innervate both the sinus region but also the meninges which surround the brain. As a result, direct determination of the site of pain origination can be confused on a cortical level. Additionally, nasal congestion is not an uncommon result of migraine headaches, further confusing the issue. A recent study further demonstrated that most patients with "sinus headache" respond to triptan migraine medications, and state dissatisfaction with their treatment when they are treated with decongestants or antibiotics.^[5]. The subtlety is that while most patient with sinusitis have some sort of facial pain, pressure, or headache, not all patients who attribute the symptom of headache to their sinuses may have legitimate diseases of the sinus. Acute and chronic sinusitis can cause pressure within the sinus cavities of the head, but this is associated with pain on palpation of the sinus area.

Diagnosis

Factors which may predispose to developing sinusitis include: allergies; structural problems such as, for example, a deviated septum, small sinus ostia; smoking; nasal polyps; carrying the cystic fibrosis gene (research is still tentative); prior bouts of sinusitis as each instance may result in increased inflammation of the nasal or sinus mucosa and potentially further narrow the openings.

Several prediction rules have been developed to aid in diagnosis based on the history and physical ^[6][7]. The most consistenly identified predictor is the presence of purulent rhinorrhea^[6][7]

When imaging techniques are required for diagnosis CT scanning is the method of choice. If allergies are suspected, allergy testing may be performed

Treatment

Acute sinusitis

There are over the counter medicines that can relieve some of the symptoms associated with sinusitis. i.e. headaches, pressure, fatigue and pain. Usually these are a combination of some kind of antihistamine along with decongestant or pain reliever. Seeing a doctor will usually result in a prescription for antibiotics and a recommended rest. Furthermore, there have been studies that have concluded allergy testing results in detection of inhaled allergens that lead to inflammation which can trigger sinusitis.^[8]

Therapeutic measures range from the medicinal to the traditional and may include nasal irrigation or jala neti using a warm saline solution, hot drinks including tea and chicken soup, inhaling steam, over-the-counter decongestants and nasal sprays, and getting plenty of rest. Analgesics (such as aspirin, paracetamol (acetaminophen) or ibuprofen) can be used, but caution must be employed to make sure the patient does not suffer from aspirin-exacerbated respiratory disease (AERD) as this could lead to anaphylaxis.

If sinusitis doesn't improve within 48 hours, or is causing significant pain, a doctor may prescribe antibiotics (Amoxicillin usually being the most common) with amoxicillin/clavulanate (Augmentin/Co-Amoxiclav) being indicated for patients who fail amoxicillin alone. Fluoroquinolones may be used in patients who are allergic to penicillins.

Chronic sinusitis

Simple measures

Nasal irrigation and flush promotes sinus cavity health, and patients with chronic sinusitis including symptoms of facial pain, headache, halitosis, cough, anterior rhinorrhea (watery discharge) and nasal congestion found nasal irrigation to be "just as effective at treating these symptoms as the drug therapies." Recently the introduction of pulsatile irrigators specifically for sinus irrigation have been reported best for nasal irrigation ^[9] In other studies, "daily hypertonic saline nasal irrigation improves sinus-related quality of life, decreases symptoms, and decreases medication use in patients with frequent sinusitis," and is "recommended as an effective adjunctive treatment of chronic sinonasal symptoms."^[10] and irrigation is recommended as an "effective adjunctive treatment of chronic sinonasal symptoms."^[11][12]

Medical approaches

For chronic or recurring sinusitis, referral to an otolaryngologist may be indicated for more specialist assessment and treatment, which may include nasal surgery.

A relatively recent advance in the treatment of sinusitis is a type of surgery called FESS - functional endoscopic sinus surgery, whereby normal clearance from the sinuses is restored by removing the anatomical and pathological obstructive variations that predispose to sinusitis. This replaces prior open techniques requiring facial or oral incisions and refocuses the technique to the natural openings of the sinuses instead of promoting drainage by gravity, the idea upon which the Caldwell-Luc surgery was based.[3]

Another recently developed treatment is Balloon Sinuplasty™. This method, similar to balloon angioplasty used to "unclog" arteries of the heart, utilizes balloons in an attempt to expand the openings of the sinuses in a less invasive manner. Its final role in the treatment of sinus disease is still under debate but appears promising.

Based on the recent theories on the role that fungus may play in the development of chronic sinusitis, newer medical therapies include topical nasal applications of antifungal agents. Much of the original research indicating fungus took place at the Mayo Clinic and they have since patented this treatment option.^[13] Although there are some licensing battles taking place over these drugs as a result of the patent, they are currently available for other uses and therefore can be compounded by pharmacies or even by the patient.

Surgical Approach

The surgical approach to the paranasal sinuses depends on the particular sinus which needs a surgical intervention and on the particular type of manipulation necessary. For this reason there are many different accesses and incisions to perform the reqired intervention in a given paranasal sinus. Examples of the approaches include: 1. Trans oral eg. the Caldwell Luc Procedure 2. Trans Nasal eg. the Naso-antral lavage and window, ethmoidectomy, sphenoidectomy. 3. Skin incision eg. Lynch procedure, osteoplastic flap, Weber Furguson approach, frontal trephine. When entry is gained into the paranasal sinus, surgery can be extended to another sinus eg. the transantral approach to the ethmoids and the sphenoid. Also it can be extended to other adjacent anatomical structures eg. transantral ligation of internal maxillary artery and transantral approach to the pterygopalatine fossa and sphenopalatine ganglion.

Other approaches

Phage therapy: Since the discovery of spontaneous bacterial lysis (from bacteriophages) by Frederick Twort and by Felix d'Herelle, phage therapy (treatment with bacterial viruses) has been used extensively with miscellaneous bacterial infections in the areas of otolaryngology, stomatology, ophthalmology, dermatology, pediatrics, gynecology, surgery (especially against wound infections), urology, and pulmonology.^[14][15][16]

Treatment with phages was developed in the Soviet Union in parallel to the western development of antibiotics. Currently phage therapy for chronic Sinusitis is available at the Phage Therapy Center, Tbilisi, Republic of Georgia,[4] or in Poland.[5]

References

• Ramadan H, Sanclement J, Thomas J (2005). "Chronic rhinosinusitis and biofilms.". Otolaryngol Head Neck Surg 132 (3): 414-7. PMID 15746854.
• Bendouah Z, Barbeau J, Hamad W, Desrosiers M (2006). "Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis.". Otolaryngol Head Neck Surg 134 (6): 991-6. PMID 16730544.

Footnotes

External links

• Sinus Headache - Medterm.com
• Sinus infection - MedicineNet.com.
• Acute sinusitis - MayoClinic.com, from the Web site of the Mayo Clinic.
• Chronic sinusitis - MayoClinic.com, from the Web site of the Mayo Clinic
• NIH
• NHS Direct
• Sinus Dynamics

v • d • e Pathology of respiratory system (J, 460–519), respiratory diseases
Acute upper respiratory infections	Upper respiratory tract infection · Common cold · Rhinitis · Sinusitis · Pharyngitis (Strep throat) · Tonsillitis · Laryngitis · Tracheitis · Croup · Epiglottitis
Influenza and Pneumonia	Influenza · Pneumonia (Viral, Bacterial, Bronchopneumonia) · Severe acute respiratory syndrome
Other acute lower respiratory infections	Bronchitis (Acute, Chronic) · Bronchiolitis
Other diseases of upper respiratory tract	Vasomotor rhinitis · Hay fever · Atrophic rhinitis · Nasal polyp · Deviated septum · Adenoid hypertrophy · Peritonsillar abscess · Vocal fold nodule · Laryngospasm
Chronic lower respiratory diseases	Emphysema · COPD · Asthma · Status asthmaticus · Bronchiectasis
Lung diseases due to external agents	Pneumoconiosis (Coalworker's pneumoconiosis, Asbestosis, Silicosis, Bauxite fibrosis, Berylliosis, Siderosis) · Byssinosis · Hypersensitivity pneumonitis (Farmer's lung, Bird fancier's lung)
Other, principally affecting the interstitium	Acute respiratory distress syndrome · Pulmonary edema · Hamman-Rich syndrome · Interstitial lung disease
Suppurative and necrotic conditions of lower respiratory tract	Lung abscess · Pleural effusion · Empyema
Other	Pneumothorax · Hemothorax · Hemopneumothorax · Mendelson's syndrome · Respiratory failure · Atelectasis · Mediastinal emphysema · Mediastinitis
see also congenital (Q30–Q34, 748)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .