Sobrerol

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Image:Sobrerol.png
Sobrerol
Systematic (IUPAC) name
(1S)-5-(1-hydroxy-1-methylethyl)-2-methylcyclohex-2-en-1-ol
Identifiers
CAS number	42370-41-2
ATC code	R05CB07
PubChem	36089
Chemical data
Formula	C10H18O2
Mol. mass	170.249 g/mol
SMILES	eMolecules & PubChem
Synonyms	trans-p-Menth-6-ene-2,8-diol; trans-sobrerol
Physical data
Melt. point	130-132 °C (-76 °F)
Boiling point	270-271 °C (-186 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Sobrerol is a mucolytic.

History

Sobrerol was discovered by Ascanio Sobrero as an oxidation product of terpenes. Later the oxidation and reduction reactions of chiral pinene lead also to several possible isomeres of Carvone and Sobrerol, making it possible to determin reaction mechanism and the strucural properties of pinene and of other terpenes.

References

• G. G. Henderson, W. J. S. Eastburn (1909). "The conversion of pinene into sobrerol". J. Chem. Soc., Trans. 95: 1465 - 1466. doi:10.1039/CT9099501465.
• H. E. Armstrong, W. J. Pope (1891). "Studies of the terpenes and allied compounds. Sobrerol, a product of the oxidation of terebenthene (oil of turpentine) in sunlight". J. Chem. Soc., Trans. 59: 315 - 320. doi:10.1039/CT8915900315.
• H. Schmidt (1953). "Über cis- und trans-Sobrerol (optisch-aktives Pinolhydrat)". Chemische Berichte 86 (11): 1437 - 1444. doi:10.1002/cber.19530861112.
• Allegra L, Bossi R, Braga PC (1981). "Action of sobrerol on mucociliary transport". Respiration 42 (2): 105-9.

Template:Pharmacology-stub

v • d • e Cough and cold preparations (R05)
Expectorants	Tyloxapol - Potassium iodide - Guaifenesin - Ipecacuanha - Althea root - Senega - Antimony pentasulfide - Creosote - Guaiacolsulfonate - Levoverbenone
Mucolytics	Acetylcysteine - Bromhexine - Carbocisteine - Eprazinone - Mesna - Ambroxol - Sobrerol - Domiodol - Letosteine - Stepronin - Tiopronin - Dornase alfa - Neltenexine - Erdosteine
Cough suppressants: Opium alkaloids and derivatives	Acetyldihydrocodeine - Benzylmorphine - Codeine - Dextromethorphan - Heroin - Dimemorfan - Ethylmorphine - Hydrocodone - Hydromorphone - Levomethadone - Levopropoxyphene - Methadone - Nicocodeine - Nicodicodeine - Normethadone - Noscapine - Pholcodine - Thebacon - Tipepidine - Zipeprol
Other cough suppressants	Benzonatate - Benproperine - Clobutinol - Diphenhydramine - Isoaminile - Pentoxyverine - Oxolamine - Oxeladin - Clofedanol - Pipazetate - Bibenzonium bromide - Butamirate - Fedrilate - Dibunate - Droxypropine - Prenoxdiazine - Dropropizine - Cloperastine - Meprotixol - Piperidione - Morclofone - Nepinalone - Levodropropizine - Dimethoxanate

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .